Sökning: WFRF:(Madariaga Maria Lucia) >
Lack of CD47 on non...
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells
-
Wang, Hui (författare)
-
Madariaga, Maria Lucia (författare)
-
Wang, Shumei (författare)
-
visa fler...
-
Van Rooijen, Nico (författare)
-
- Oldenborg, Per-Arne (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
-
Yang, Yong-Guang (författare)
-
visa färre...
-
(creator_code:org_t)
- 2007-08-21
- 2007
- Engelska.
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National academy of sciences. - 0027-8424 .- 1091-6490. ; 104:34, s. 13744-13749
- Relaterad länk:
-
http://www.pnas.org/...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Macrophages recognize CD47 as a marker of "self" and phagocytose CD47null hematopoietic cells. Using CD47 chimera models, here, we show that the phagocytic activity of macrophages against CD47null hematopoietic cells is conferred by CD47 expression on nonhematopoietic cells, and this "education" process is hematopoietic cell-independent. Macrophages in the chimeras where nonhematopoietic cells express CD47 phagocytose CD47null cells, whereas those in the chimeras lacking CD47 on nonhematopoietic cells are tolerant to CD47null cells. However, macrophages in the latter chimeras retain phagocytic activity against CD47null RBCs, demonstrating a split macrophage tolerance to CD47null hematopoietic cells. The findings highlight the potential importance of nonhematopoietic cells in the regulation of macrophage function, and suggest a previously uncharacterized mechanism of macrophage tolerance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- chimera
- phagocytosis
- signaling regulatory protein-alpha
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas