Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis

TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in this gene. TAP2 is of particular interest because its involvement in antigen presentation makes it a candidate for a disease susceptibility gene. In psoriasis, two clinical subtypes analogous to the situation in diabetes type I with early onset and family history and type II with later onset and without family history have been described. We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 haplotype. To investigate whether this haplotype extends to include particular TAP2 and/or DP alleles, we tested the TAP2 and HLA-DP alleles of a control group (n = 199), patients with psoriasis type I (n = 66), and patients with psoriasis type II (n = 35) by hybridization with SSOs. Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or type II. We conclude that disease association in type I psoriasis is associated with the extended haplotype HLA-B57, -Cw6, -DRB1*0701/2, -DQA1*0201, -DQB1*0303.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
mhc class-ii; major histocompatibility complex; oligonucleotide probes; langerhans cells; antigen; transporter; molecules; dna; expression; autoimmunity

Schmitt-Egenolf, MarcusDepartment of Dermatology, University of Ulm, Ulm, Germany(Swepub:umu)masc0001 (författare)
Vejbaesya, S (författare)
Boehncke, WH (författare)
Sterry, W (författare)
Eiermann, TH (författare)
Department of Dermatology, University of Ulm, Ulm, Germany (creator_code:org_t)

Av författaren/redakt...: Fakler, JW; Schmitt-Egenolf, ...; Vejbaesya, S; Boehncke, WH; Sterry, W; Eiermann, TH

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Dermatologi och ...

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