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The expression of a...
The expression of androgen receptors in human neck and limb muscles : effects of training and self-administration of androgenic-anabolic steroids
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- Kadi, Fawzi (författare)
- Umeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology
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- Bonnerud, P (författare)
- Umeå universitet,Anatomi
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- Eriksson, Anders (författare)
- Umeå universitet,Anatomi
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- Thornell, Lars-Eric (författare)
- Umeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2000
- 2000
- Engelska.
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Ingår i: Histochemistry and Cell Biology. - : Springer Science and Business Media LLC. - 0948-6143 .- 1432-119X. ; 113:1, s. 25-29
- Relaterad länk:
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0. 05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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