Sökning: WFRF:(German J. Bruce) >
Individual Variatio...
Individual Variation in Lipidomic Profiles of Healthy Subjects in Response to Omega-3 Fatty Acids
-
- Nording, Malin Linder (författare)
- Umeå universitet,Kemiska institutionen
-
Yang, Jun (författare)
-
Georgi, Katrin (författare)
-
visa fler...
-
Karbowski, Christine Hegedus (författare)
-
German, J. Bruce (författare)
-
Weiss, Robert H. (författare)
-
Hogg, Ronald J. (författare)
-
- Trygg, Johan (författare)
- Umeå universitet,Kemiska institutionen,Computational Life Science Cluster (CLiC)
-
Hammock, Bruce D. (författare)
-
Zivkovic, Angela M. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2013-10-24
- 2013
- Engelska.
-
Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 8:10, s. e76575-
- Relaterad länk:
-
https://umu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Introduction: Conflicting findings in both interventional and observational studies have resulted in a lack of consensus on the benefits of omega 3 fatty acids in reducing disease risk. This may be due to individual variability in response. We used a multi-platform lipidomic approach to investigate both the consistent and inconsistent responses of individuals comprehensively to a defined omega 3 intervention. Methods: The lipidomic profile including fatty acids, lipid classes, lipoprotein distribution, and oxylipins was examined multi- and uni-variately in 12 healthy subjects pre vs. post six weeks of omega 3 fatty acids (1.9 g/d eicosapentaenoic acid [EPA] and 1.5 g/d docosahexaenoic acid [DHA]). Results: Total lipidomic and oxylipin profiles were significantly different pre vs. post treatment across all subjects (p=0.00007 and p=0.00002 respectively). There was a strong correlation between oxylipin profiles and EPA and DHA incorporated into different lipid classes (r(2)=0.93). However, strikingly divergent responses among individuals were also observed. Both omega 3 and omega 6 fatty acid metabolites displayed a large degree of variation among the subjects. For example, in half of the subjects, two arachidonic acid cyclooxygenase products, prostaglandin E-2 (PGE(2)) and thromboxane B2 (TXB2), and a lipoxygenase product, 12-hydroxyeicosatetraenoic acid (12-HETE) significantly decreased post intervention, whereas in the other half they either did not change or increased. The EPA lipoxygenase metabolite 12-hydroxyeicosapentaenoic acid (12-HEPE) varied among subjects from an 82% decrease to a 5,000% increase. Conclusions: Our results show that certain defined responses to omega 3 fatty acid intervention were consistent across all subjects. However, there was also a high degree of inter-individual variability in certain aspects of lipid metabolism. This lipidomic based phenotyping approach demonstrated that individual responsiveness to omega 3 fatty acids is highly variable and measurable, and could be used as a means to assess the effectiveness of omega 3 interventions in modifying disease risk and determining metabolic phenotype.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
PLOS ONE
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Nording, Malin L ...
-
Yang, Jun
-
Georgi, Katrin
-
Karbowski, Chris ...
-
German, J. Bruce
-
Weiss, Robert H.
-
visa fler...
-
Hogg, Ronald J.
-
Trygg, Johan
-
Hammock, Bruce D ...
-
Zivkovic, Angela ...
-
visa färre...
- Artiklar i publikationen
-
PLOS ONE
- Av lärosätet
-
Umeå universitet