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Epidemiology of Res...
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Moyes, Jocelyn
(författare)
Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection Hospitalizations Among HIV-Infected and HIV-Uninfected South African Children, 2010-2011
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-11-21
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Oxford University Press,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-85086
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85086URI
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https://doi.org/10.1093/infdis/jit479DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background. There are limited data on respiratory syncytial virus (RSV) infection among children in settings with a high prevalence of human immunodeficiency virus (HIV). We studied the epidemiology of RSV-associated acute lower respiratory tract infection (ALRTI) hospitalizations among HIV-infected and HIV-uninfected children in South Africa. Methods. Children aged <5 years admitted to sentinel surveillance hospitals with physician-diagnosed neonatal sepsis or ALRTI were enrolled. Nasopharyngeal aspirates were tested by multiplex real-time polymerase chain reaction assays for RSV and other viruses. Associations between possible risk factors and severe outcomes for RSV infection among HIV-infected and uninfected children were examined. The relative risk of hospitalization in HIV-infected and HIV-uninfected children was calculated in 1 site with population denominators. Results. Of 4489 participants, 4293 (96%) were tested for RSV, of whom 1157 (27%) tested positive. With adjustment for age, HIV-infected children had a 3-5-fold increased risk of hospitalization with RSV-associated ALRTI (2010 relative risk, 5.6; [95% confidence interval (CI), 4.5-6.4]; 2011 relative risk, 3.1 [ 95% CI, 2.6-3.6]). On multivariable analysis, HIV-infected children with RSV-associated ALRTI had higher odds of death (adjusted odds ratio. 31.1; 95% CI, 5.4-179.8) and hospitalization for >5 days (adjusted odds ratio, 4.0; 95% CI, 1.5-10.6) than HIV-uninfected children. Conclusion. HIV-infected children have a higher risk of hospitalization with RSV-associated ALRTI and a poorer outcome than HIV-uninfected children. These children should be targeted for interventions aimed at preventing severe RSV disease.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Cohen, Cheryl
(författare)
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Pretorius, Marthi
(författare)
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Groome, Michelle
(författare)
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von Gottberg, Anne
(författare)
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Wolter, Nicole
(författare)
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Walaza, Sibongile
(författare)
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Haffejee, Sumayya
(författare)
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Chhagan, Meera
(författare)
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Naby, Fathima
(författare)
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Cohen, Adam L.
(författare)
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Tempia, Stefano
(författare)
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Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,INDEPTH network, Accra, Ghana(Swepub:umu)kaka0045
(författare)
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Dawood, Halima
(författare)
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Venter, Marietjie
(författare)
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Madhi, Shabir A.
(författare)
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Umeå universitetEpidemiologi och global hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Infectious Diseases: Oxford University Press208:Supplement: 3, s. S217-S2260022-18991537-6613
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Moyes, Jocelyn
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Cohen, Cheryl
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Pretorius, Marth ...
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Groome, Michelle
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von Gottberg, An ...
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Wolter, Nicole
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Walaza, Sibongil ...
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Haffejee, Sumayy ...
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Chhagan, Meera
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Naby, Fathima
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Cohen, Adam L.
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Tempia, Stefano
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Kahn, Kathleen
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Dawood, Halima
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Venter, Marietji ...
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Madhi, Shabir A.
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