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The CD8alpha+ dendr...
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Belz, Gabrielle TImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
The CD8alpha+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
- Artikel/kapitelEngelska2002
Förlag, utgivningsår, omfång ...
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2002-10-14
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The Rockefeller University Press,2002
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LIBRIS-ID:oai:DiVA.org:umu-87524
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87524URI
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https://doi.org/10.1084/jem.20020861DOI
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Språk:engelska
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Sammanfattning på:engelska
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We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow-derived cell type that stimulates the proliferation and ultimate deletion of self-reactive CD8 T cells. This process has been referred to as cross-tolerance. Here, we characterize the elusive cell type responsible for inducing cross-tolerance as a CD8alpha(+) dendritic cell (DC). To achieve this aim, transgenic mice were generated expressing yellow fluorescent protein (YFP) linked to CTL epitopes for ovalbumin and glycoprotein B (gB) of herpes simplex virus under the rat insulin promoter (RIP). Although tracking of YFP was inconclusive, the use of a highly sensitive gB-specific hybridoma that produced beta-galactosidase on encounter with antigen, enabled detection of antigen presentation by cells isolated from the pancreatic lymph node. This showed that a CD11c(+)CD8alpha(+) cell was responsible for cross-tolerance, the same DC subset as previously implicated in cross-priming. These data indicate that CD8alpha(+) DCs play a critical role in both tolerance and immunity to cell-associated antigens, providing a potential mechanism by which cytotoxic T lymphocyte can be immunized to viral antigens while maintaining tolerance to self.
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Behrens, Georg M NImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
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Smith, Chris MImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
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Miller, Jacques F A PImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
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Jones, ClaerwenDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
(författare)
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Lejon, Kristina,1967-Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA(Swepub:umu)krle0001
(författare)
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Fathman, C. GarrisonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
(författare)
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Mueller, Scott NDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
(författare)
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Shortman, KenImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
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Carbone, Francis RDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
(författare)
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Heath, William RImmunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
(författare)
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Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, AustraliaDepartment of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Experimental Medicine: The Rockefeller University Press196:8, s. 1099-11040022-10071540-9538
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Belz, Gabrielle ...
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Behrens, Georg M ...
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Smith, Chris M
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Miller, Jacques ...
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Jones, Claerwen
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Lejon, Kristina, ...
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Fathman, C. Garr ...
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Mueller, Scott N
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Shortman, Ken
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Carbone, Francis ...
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Heath, William R
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