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Job strain and the ...
Job strain and the risk of inflammatory bowel diseases : individual-participant meta-analysis of 95 000 men and women
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- Heikkila, Katriina (författare)
- Finnish Institute of Occupational Health, Helsinki, Finland
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- Madsen, Ida E. H. (författare)
- National Research Centre for the Working Environment, Copenhagen, Denmark
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- Theorell, Töres (författare)
- Stockholms universitet,Karolinska Institutet,Stressforskningsinstitutet
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- Fransson, Eleonor (författare)
- Stockholms universitet,Karolinska Institutet,Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,Stressforskningsinstitutet,Karolinska Institutet, Sweden; Jönköping University, Sweden
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- Ahola, Kirsi (författare)
- Finnish Institute of Occupational Health, Helsinki, Finland
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- Alfredsson, Lars (författare)
- Karolinska Institutet
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- Bjorner, Jakob B. (författare)
- National Research Centre for the Working Environment, Copenhagen, Denmark
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- Borritz, Marianne (författare)
- Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
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- Burr, Hermann (författare)
- Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany
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- Dragano, Nico (författare)
- Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany
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- Ferrie, Jane E. (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom,School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom
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- Knutsson, Anders (författare)
- Mittuniversitetet,Avdelningen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden
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- Koskenvuo, Markku (författare)
- Department of Public Health, University of Helsinki, Helsinki, Finland
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- Koskinen, Aki (författare)
- Finnish Institute of Occupational Health, Helsinki, Finland
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- Nielsen, Martin L. (författare)
- Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
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- Nordin, Maria (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Pejtersen, Jan H. (författare)
- The Danish National Centre for Social Research, Copenhagen, Denmark
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- Pentti, Jaana (författare)
- Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
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- Rugulies, Reiner (författare)
- National Research Centre for the Working Environment, Copenhagen, Denmark
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- Oksanen, Tuula (författare)
- Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
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- Shipley, Martin J. (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom
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- Suominen, Sakari B. (författare)
- Folkhälsan Research Center, Helsinki, Finland
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Theorell, Tores (författare)
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- Vaananen, Ari (författare)
- Finnish Institute of Occupational Health, Helsinki, Finland
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- Vahtera, Jussi (författare)
- Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
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- Virtanen, Marianna (författare)
- Finnish Institute of Occupational Health, Helsinki, Finland
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- Westerlund, Hugo (författare)
- Stockholms universitet,Stressforskningsinstitutet
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- Westerholm, Peter J. M. (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Batty, G. David (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom
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- Singh-Manoux, Archana (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom
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- Kivimaki, Mika (författare)
- Department of Epidemiology and Public Health, University College London, London, United Kingdom,Finnish Institute of Occupational Health, Helsinki, Finland
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(creator_code:org_t)
- 2014-02-18
- 2014
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2, s. e88711-
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Abstract
Ämnesord
Stäng
- Background and Aims: Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95 000 European adults. Methods: We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study-specific results were combined in random effects meta-analyses. Results: Of the 95 379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn's disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn's disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 0.48, 1.43) or ulcerative colitis (hazard ratio: 1.06, 95% CI: 0.76, 1.48). There was negligible heterogeneity among the study-specific associations. Conclusions: Our findings suggest that job strain, an indicator of work-related stress, is not a major risk factor for Crohn's disease or ulcerative colitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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Heikkila, Katrii ...
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Madsen, Ida E. H ...
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Theorell, Töres
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Fransson, Eleono ...
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Ahola, Kirsi
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Alfredsson, Lars
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Bjorner, Jakob B ...
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Borritz, Mariann ...
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Burr, Hermann
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Dragano, Nico
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Ferrie, Jane E.
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Knutsson, Anders
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Koskenvuo, Markk ...
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Koskinen, Aki
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Nielsen, Martin ...
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Nordin, Maria
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Pejtersen, Jan H ...
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Pentti, Jaana
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Rugulies, Reiner
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Oksanen, Tuula
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Shipley, Martin ...
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Suominen, Sakari ...
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Theorell, Tores
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Vaananen, Ari
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Vahtera, Jussi
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Virtanen, Marian ...
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Westerlund, Hugo
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Westerholm, Pete ...
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Batty, G. David
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Singh-Manoux, Ar ...
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Kivimaki, Mika
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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och Psykologi
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Umeå universitet
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Mittuniversitetet
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Jönköping University
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Karolinska Institutet
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Stockholms universitet
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Uppsala universitet