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Insulin-like growth...
Insulin-like growth factor-I and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition
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Schmidt, Julie A (author)
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Allen, Naomi E (author)
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Franceschi, Silvia (author)
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Rinaldi, Sabina (author)
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Tipper, Sarah J (author)
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Tsilidis, Konstantinos K (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Overvad, Kim (author)
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Tjønneland, Anne (author)
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Boutron-Ruault, Marie-Christine (author)
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Dossus, Laure (author)
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Mesrine, Sylvie (author)
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Kaaks, Rudolf (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi
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Boeing, Heiner (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Trichopoulou, Antonia (author)
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Palli, Domenico (author)
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Krogh, Vittorio (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Zanetti, Roberto (author)
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Bueno-de-Mesquita, H Bas (author)
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Peeters, Petra H M (author)
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Lund, Eiliv (author)
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Menéndez, Virginia (author)
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Agudo, Antonio (author)
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Sanchez, Maria-Jose (author)
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Chirlaque, Maria-Dolores (author)
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Ardanaz, Eva (author)
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Larranaga, Nerea (author)
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- Hennings, Joakim, 1969- (author)
- Umeå universitet,Kirurgi
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- Sandström, Maria (author)
- Umeå universitet,Onkologi
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Khaw, Kay-Tee (author)
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Wareham, Nicholas (author)
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Romieu, Isabelle (author)
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Gunter, Marc J (author)
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Riboli, Elio (author)
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Key, Timothy J (author)
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Travis, Ruth C (author)
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Wareham, Nick (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 23:6, s. 976-985
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- Background: Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and anti-apoptotic properties. Methods: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study centre, sex, and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at blood collection. Serum IGF-I concentrations were measured by immunoassay, and risk of differentiated thyroid cancer in relation to IGF-I concentration was estimated using conditional logistic regression. Results: There was a positive association between IGF-I concentrations and risk of differentiated thyroid carcinoma: the odds ratio for a doubling in IGF-I concentration was 1.48 (95% confidence interval: 1.06 - 2.08; ptrend = 0.02). The positive association with IGF-I was stable over time between blood collection and cancer diagnosis. Conclusion: These findings suggest that IGF-I concentrations may be positively associated with risk of differentiated thyroid carcinoma. Impact: This study provides the first prospective evidence of a potential association between circulating IGF-I concentrations and risk of differentiated thyroid carcinoma and may prompt the further investigations needed to confirm the association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schmidt, Julie A
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Allen, Naomi E
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Almquist, Martin
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Franceschi, Silv ...
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Rinaldi, Sabina
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Tipper, Sarah J
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show more...
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Tsilidis, Konsta ...
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Weiderpass, Elis ...
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Overvad, Kim
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Tjønneland, Anne
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Boutron-Ruault, ...
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Dossus, Laure
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Mesrine, Sylvie
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Kaaks, Rudolf
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Lukanova, Anneka ...
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Boeing, Heiner
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Lagiou, Pagona
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Trichopoulos, Di ...
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Trichopoulou, An ...
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Palli, Domenico
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Krogh, Vittorio
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Panico, Salvator ...
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Tumino, Rosario
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Zanetti, Roberto
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Lund, Eiliv
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Menéndez, Virgin ...
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Agudo, Antonio
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Sanchez, Maria-J ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Larranaga, Nerea
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Hennings, Joakim ...
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Sandström, Maria
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Romieu, Isabelle
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Gunter, Marc J
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Riboli, Elio
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Key, Timothy J
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Travis, Ruth C
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Wareham, Nick
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet