Search: id:"swepub:oai:DiVA.org:umu-8814" >
Phase-contrast micr...
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Janson, VeronicaUmeå universitet,Klinisk kemi
(author)
Phase-contrast microscopy studies of early Cisplatin-induced morphological changes of malignant mesothelioma cells and the correspondence to induced apoptosis
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2009-07-02
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Taylor & Francis,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-8814
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-8814URI
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https://doi.org/10.1080/01902140701884398DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cisplatin treatment efficacy of malignant pleural mesothelioma (MPM) is aggravated by resistance and adverse effects. In P31 MPM cells, cisplatin induces morphological changes and apoptosis. To determine if very early (10 minutes) morphological responses corresponded to apoptosis-induction, cisplatin effects on P31 morphology were examined with phase-contrast microscopy (PCM), scanning electron microscopy (SEM), and flow cytometry (fluorescence-activated cell sorting [FACS]), and compared to apoptosis-induction over time. Increased membrane protrusions were identified with PCM and SEM, but these were not consistent with the induction of apoptosis. The authors concluded that very early morphological changes can be determined with PCM in MPM, but they did not convincingly correspond to apoptosis induction.
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Behnam-Motlagh, ParvizUmeå universitet,Klinisk kemi(Swepub:umu)pabe0001
(author)
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Henriksson, RogerUmeå universitet,Onkologi(Swepub:umu)rohe0003
(author)
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Hörstedt, PerUmeå universitet,Patologi(Swepub:umu)peho0001
(author)
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Engström, Karl GunnarUmeå universitet,Kirurgi(Swepub:umu)kaen0006
(author)
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Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002
(author)
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Umeå universitetKlinisk kemi
(creator_code:org_t)
Related titles
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In:Experimental Lung Research: Taylor & Francis34:2, s. 49-670190-21481521-0499
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