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Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Thompson, AAR (author)
Elks, PM (author)
Marriott, HM (author)
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Eamsamarng, S (author)
Higgins, KR (author)
Lewis, A (author)
Williams, L (author)
Parmar, S (author)
Shaw, G (author)
McGrath, EE (author)
Formenti, F (author)
Van Eeden, FJ (author)
Kinnula, VL (author)
Pugh, CW (author)
Sabroe, I (author)
Dockrell, DH (author)
Chilvers, ER (author)
Robbins, PA (author)
Percy, MJ (author)
Simon, MC (author)
Johnson, RS (author)
Karolinska Institutet
Renshaw, SA (author)
Whyte, MKB (author)
Walmsley, SR (author)
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 (creator_code:org_t)
American Society of Hematology, 2014
2014
English.
In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 123:3, s. 366-376
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Neutrophil lifespan is extended in patients with gain-of-function HIF2A mutations. HIF-2α regulates in vivo neutrophil longevity and thus tissue inflammation and repair.

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