Search: (WFRF:(Gunter Marc J.)) pers:(Peeters Petra H) pers:(Palli Domenico)
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Biomarker patterns ...
Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer : results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Aleksandrova, Krasimira (author)
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Jenab, Mazda (author)
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Bueno-de-Mesquita, H. Bas (author)
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Fedirko, Veronika (author)
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Kaaks, Rudolf (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi
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van Duijnhoven, Franzel J. B. (author)
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Jansen, Eugene (author)
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Rinaldi, Sabina (author)
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Romieu, Isabelle (author)
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Ferrari, Pietro (author)
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Murphy, Neil (author)
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Gunter, Marc J. (author)
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Riboli, Elio (author)
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Westhpal, Sabine (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Halkjaer, Jytte (author)
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Boutron-Ruault, Marie-Christine (author)
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Dossus, Laure (author)
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Racine, Antoine (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Orfanos, Philippos (author)
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Agnoli, Claudia (author)
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Palli, Domenico (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Peeters, Petra H. (author)
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Duell, Eric J. (author)
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Molina-Montes, Esther (author)
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Ramon Quiros, J. (author)
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Dorronsoro, Miren (author)
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Chirlaque, Maria-Dolores (author)
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Barricarte, Aurelio (author)
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- Ljuslinder, Ingrid (author)
- Umeå universitet,Onkologi
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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Travis, Ruth C. (author)
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Khaw, Kay-Tee (author)
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Wareham, Nicholas (author)
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Pischon, Tobias (author)
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Boeing, Heiner (author)
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(creator_code:org_t)
- 2014-05-04
- 2014
- English.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 29:4, s. 261-275
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60 % of the overall biomarker variance. In multivariable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95 % CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95 % CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95 % CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95 % CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as biomarker patterns representing potentially important pathways for CRC development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Colorectal cancer
- Biomarker patterns
- Inflammatory and metabolic pathways
- Principal component analysis
- European Prospective Investigation into Cancer and Nutrition (EPIC)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aleksandrova, Kr ...
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Jenab, Mazda
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Bueno-de-Mesquit ...
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Fedirko, Veronik ...
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Kaaks, Rudolf
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Lukanova, Anneka ...
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show more...
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van Duijnhoven, ...
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Jansen, Eugene
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Rinaldi, Sabina
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Romieu, Isabelle
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Ferrari, Pietro
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Murphy, Neil
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Gunter, Marc J.
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Riboli, Elio
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Westhpal, Sabine
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Overvad, Kim
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Tjonneland, Anne
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Halkjaer, Jytte
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Boutron-Ruault, ...
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Dossus, Laure
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Racine, Antoine
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Trichopoulou, An ...
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Bamia, Christina
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Orfanos, Philipp ...
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Agnoli, Claudia
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Palli, Domenico
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Panico, Salvator ...
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Tumino, Rosario
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Vineis, Paolo
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Peeters, Petra H ...
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Duell, Eric J.
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Molina-Montes, E ...
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Ramon Quiros, J.
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Dorronsoro, Mire ...
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Chirlaque, Maria ...
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Barricarte, Aure ...
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Ljuslinder, Ingr ...
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Palmqvist, Richa ...
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Travis, Ruth C.
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Pischon, Tobias
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Boeing, Heiner
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University