Epidemiology of Influenza Virus Types and Subtypes in South Africa, 2009-2012

To determine clinical and epidemiologic differences between influenza caused by different virus types and subtypes, we identified patients and tested specimens. Patients were children and adults hospitalized with confirmed influenza and severe acute respiratory illness (SARI) identified through active, prospective, hospital-based surveillance from 2009-2012 in South Africa. Respiratory specimens were tested, typed, and subtyped for influenza virus by PCR. Of 16,005 SARI patients tested, 1,239 (8%) were positive for influenza virus. Patient age and co-infections varied according to virus type and subtype, but disease severity did not. Case-patients with influenza B were more likely than patients with influenza A to be HIV infected. A higher proportion of case-patients infected during the first wave of the 2009 influenza pandemic were 5-24 years of age (19%) than were patients infected during the second wave (9%). Although clinical differences exist, treatment recommendations do not differ according to subtype; prevention through vaccination is recommended.

Hellferscee, Orienka (author)
Pretorius, Marthi (author)
Treurnicht, Florette (author)
Walaza, Sibongile (author)
Madhi, Shabir (author)
Groome, Michelle (author)
Dawood, Halima (author)
Variava, Ebrahim (author)
Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,University of Witwatersrand, Johannesburg, South Africa and INDEPTH Network, Accra, Ghana(Swepub:umu)kaka0045 (author)
Wolter, Nicole (author)
von Gottberg, Anne (author)
Tempia, Stefano (author)
Venter, Marietjie (author)
Cohen, Cheryl (author)
Umeå universitetEpidemiologi och global hälsa (creator_code:org_t)

In:Emerging Infectious DiseasesAtlanta, USA : Centers Disease Control20:7, s. 1162-11691080-60401080-6059

By the author/editor: Cohen, Adam L.; Hellferscee, Ori ...; Pretorius, Marth ...; Treurnicht, Flor ...; Walaza, Sibongil ...; Madhi, Shabir; show more...; Groome, Michelle; Dawood, Halima; Variava, Ebrahim; Kahn, Kathleen; Wolter, Nicole; von Gottberg, An ...; Tempia, Stefano; Venter, Marietji ...; Cohen, Cheryl; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

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