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Early death and CSF...
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Carlborg, AndreasKarolinska Institutet
(författare)
Early death and CSF monoamine metabolites in schizophrenia spectrum psychosis
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-07-22
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Informa UK Limited,2011
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-92339
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92339URI
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https://doi.org/10.3109/08039488.2010.503903DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:122339182URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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INTRODUCTION: Patients with schizophrenia have higher rates of mortality than the general population. Lower concentrations of the cerebrospinal fluid (CSF) monoamine metabolites homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) have been associated with suicidal, aggressive and impulsive behavior. Mortality has been suggested as a measure of impulsivity and a relationship between early death and lower concentrations of CSF monoamine metabolites has been reported but the studies are few with short periods of follow-up and small numbers.AIM: The objective of this study was to investigate a relationship between early death and concentrations of CSF 5-HIAA and HVA.METHODS: Three hundred and eighty-five inpatients with schizophrenia spectrum psychosis were lumbar punctured in a standardized manner and followed for a median of 26 years. Patients were searched to identify those who had died. Causes of death were obtained from the Causes of Death Register.RESULTS: During the time of follow-up, 97 patients died. Schizophrenia spectrum psychosis patients died at an earlier age from both natural and unnatural causes of death. No significant associations were found between CSF 5-HIAA and HVA concentrations and non-suicidal death. Attempted suicide was not a risk factor for non-suicidal death at younger age.CONCLUSION: Patients with schizophrenia spectrum psychosis die at an earlier age from both natural and unnatural causes of death. Attempted suicide is not a risk factor for non-suicidal death at younger age. Low concentrations of CSF HVA and 5-HIAA were not a risk factor for non-suicidal death at younger age in schizophrenia spectrum psychosis.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jokinen, JussiKarolinska Institutet(Swepub:umu)jujo0022
(författare)
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Nordström, Anna-LenaKarolinska Inst, Dept Clin Neurosci, Karolinska Univ Hosp, Solna, Sweden
(författare)
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Jönsson, Erik GKarolinska Institutet
(författare)
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Nordström, PeterKarolinska Institutet
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Clin Neurosci, Karolinska Univ Hosp, Solna, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nordic Journal of Psychiatry: Informa UK Limited65:2, s. 101-50803-94881502-4725
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