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Comprehensive analy...
Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma
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Bethke, Lara (author)
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Webb, Emily (author)
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Murray, Anne (author)
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Schoemaker, Minouk (author)
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Johansen, Christoffer (author)
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Collatz Christensen, Helle (author)
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Muir, Kenneth (author)
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McKinney, Patricia (author)
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Hepworth, Sarah (author)
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Dimitropoulou, Polyxeni (author)
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Lophatananon, Artitaya (author)
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- Feychting, Maria (author)
- Karolinska Institutet
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- Lönn, Stefan (author)
- Karolinska Institutet
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- Ahlbom, Anders (author)
- Karolinska Institutet
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- Malmer, Beatrice (author)
- Umeå universitet,Onkologi
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- Henriksson, Roger (author)
- Umeå universitet,Onkologi
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Auvinen, Anssi (author)
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Kiuru, Anne (author)
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Salminen, Tiina (author)
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Swerdlow, Anthony (author)
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Houlston, Richard (author)
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(creator_code:org_t)
- 2007-11-29
- 2008
- English.
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 17:6, s. 800-805
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Much of the variation in inherited risk of glioma is likely to be explained by combinations of common low risk variants. The established relationship between glioma risk and exposure to ionizing radiation led us to examine whether variants in the DNA repair genes contribute to disease susceptibility. We evaluated 1127 haplotype-tagging single-nucleotide polymorphisms (SNPs) supplemented with 388 putative functional SNPs to capture most of the common variation in 136 DNA repair genes, in five unique case–control series from four different countries (1013 cases, 1016 controls). We identified 16 SNPs associated with glioma risk at the 1% significance level. The highest association observed across the five independent case–control datasets involved rs243356, which maps to intron 3 of CHAF1A (trend odds ratio, 1.32; 95% confidence interval 1.14–1.54; P = 0.0002; false-positive report probability = 0.055, based on a prior probability of 0.01). Our results provide additional support for the hypothesis that low penetrance variants contribute to the risk of developing glioma and suggest that a genetic variant located in or around the CHAF1A gene contributes to disease risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- polymorphism
- genes
- glioma
- haplotypes
- introns
- single nucleotide polymorphism
- dna repair gene
- false-positive results
- maps
- datasets
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bethke, Lara
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Webb, Emily
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Murray, Anne
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Schoemaker, Mino ...
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Johansen, Christ ...
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Collatz Christen ...
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show more...
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Muir, Kenneth
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McKinney, Patric ...
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Hepworth, Sarah
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Dimitropoulou, P ...
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Lophatananon, Ar ...
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Feychting, Maria
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Lönn, Stefan
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Ahlbom, Anders
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Malmer, Beatrice
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Henriksson, Roge ...
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Auvinen, Anssi
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Kiuru, Anne
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Salminen, Tiina
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Swerdlow, Anthon ...
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Human Molecular ...
- By the university
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Umeå University
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Karolinska Institutet