Significant beat-to-beat variability of E/e’ irrespective of respiration

Grönlund, Christer,1975-Umeå universitet,Institutionen för strålningsvetenskaper (författare)

The E/e’ ratio is commonly used in Doppler echocardiographic examinations to estimate the pulmonary capillary wedge pressure. The rationale of using this ratio is to combine left ventricular (LV) filling (E) and relaxation (e’) velocities to indirectly assess left atrial pressure. However, the accuracy of this index has recently been questioned, particularly in patients with controlled heart failure. Likewise, the potential beat-to-beat variability of such measurements remains undetermined. The cardiovascular system is subject to several oscillations with the potential of influencing LV function and its intra-cavitary pressures, hence measurements of its filling and relaxation velocities. The aim of this pilot study was to assess the beat-to-beat variability of the E/e’ ratio in one minute long examination in healthy subjects, and patients with various severity of amyloid heart disease. The results show that despite critical application of the standard echocardiographic recording recommendations, E/e’ beat-to-beat variability was 36 % (22 to 50%) in healthy subjects and 17 % (11-26%) in patients, and where the most severe amyloid heart disease had the least variability. Thus, clinical use of a single or few cardiac beats might not necessarily reflect an accurate ratio between the two velocities, and hence casts doubt over their diagnostic value.

Albano, Amanda (författare)
Gustavsson, SandraUmeå universitet,Kardiologi(Swepub:umu)sagu0005 (författare)
Wiklund, Urban (författare)
Henein, Michael YUmeå universitet,Kardiologi(Swepub:umu)mihe0015 (författare)
Lindqvist, PerUmeå universitet,Klinisk fysiologi(Swepub:umu)peli0011 (författare)
Umeå universitetInstitutionen för strålningsvetenskaper (creator_code:org_t)

Ingår i:International cardiovascular forum: Barcaray Publishing1:2, s. 88-892409-34242410-2636

Av författaren/redakt...: Grönlund, Christ ...; Albano, Amanda; Gustavsson, Sand ...; Wiklund, Urban; Henein, Michael ...; Lindqvist, Per

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk bildbe ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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