High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide

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Isung, JKarolinska Institutet (author)

High interleukin-6 and impulsivity : determining the role of endophenotypes in attempted suicide

Article/chapterEnglish2014

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2014-10-21
Nature Publishing Group,2014
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-96377
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96377URI
https://doi.org/10.1038/tp.2014.113DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:130123610URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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The dysregulation of inflammation has been associated with depression and, more recently, with suicidal behaviors. The reports regarding the relationship between interleukin-6 (IL-6) and suicide attempts are inconsistent. Personality traits such as impulsivity and aggression are considered endophenotypes and important factors that underlie suicidal behaviors. The aim of the current study was to assess whether plasma and cerebrospinal fluid (CSF) levels of IL-6 are associated with personality traits among suicide attempters. We assessed the relationships among personality traits, IL-6 and violent suicide attempts. The plasma and CSF levels of IL-6 were measured in suicide attempters (plasma=58, CSF=39) using antibody-based immunoassay systems. Personality domains were assessed using the Karolinska Scale of Personality (KSP). IL-6 levels in plasma and CSF were used to predict personality domains via regression models. Plasma IL-6 was significantly and positively correlated with extraversion as well as the KSP subscales impulsivity and monotony avoidance. CSF IL-6 was positively correlated with monotony avoidance. Violent suicide attempts tended to be associated with high plasma IL-6 levels. Plasma and CSF levels of IL-6 were not significantly associated with each other. These results indicate that impulsivity and the choice of a violent suicide attempt method might be related to higher levels of IL-6 in individuals who attempt suicide. The neuroinflammation hypothesis of suicidal behavior on the basis of elevated IL-6 levels might be partly explained by the positive association between IL-6 and impulsivity, which is a key element of the suicidal phenotype.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng

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Aeinehband, SKarolinska Institutet (author)
Mobarrez, FKarolinska Institutet (author)
Nordström, PKarolinska Institutet (author)
Runeson, BKarolinska Institutet (author)
Asberg, MKarolinska Institutet (author)
Piehl, FKarolinska Institutet (author)
Jokinen, JussiKarolinska Institutet,Umeå universitet,Psykiatri,Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden(Swepub:umu)jujo0022 (author)
Karolinska InstitutetPsykiatri (creator_code:org_t)

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In:Translational Psychiatry: Nature Publishing Group4:e4702158-3188

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By the author/editor: Isung, J; Aeinehband, S; Mobarrez, F; Nordström, P; Runeson, B; Asberg, M; show more...; Piehl, F; Jokinen, Jussi; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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By the university: Umeå University; Karolinska Institutet

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