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  • Nzenze, S. A. (author)

Temporal association of infant immunisation with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonisation in a rural South African community

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • Elsevier,2014
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-96515
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96515URI
  • https://doi.org/10.1016/j.vaccine.2014.06.091DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Immunisation of children with pneumococcal conjugate vaccines (PCV) may affect the bacterial-ecology of the nasopharynx, including colonisation by Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus. The aim of this study was to evaluate the effect of infant PCVimmunisation on the nasopharyngeal ecology of these potentially pathogenic bacteria in a rural African setting. Methods: Two cross sectional surveys were undertaken from May to October in 2009 (Period-1) which coincided with the introduction of 7-valent PCV (PCV7) and in May-October 2011 (Period-2). Consenting household members, where there was a child <2 years of age in residence, had nasopharyngeal swabs undertaken for culture. Results: From Period-1 to Period-2 in children 0-2 years and 3-12 years, prevalence of overall S. pneumoniae colonisation decreased from 74.9% to 67.0% (p < 0.001) and H. influenzae declined among children 3-12 years (55.1-45.3%, p < 0.001) but not among those <2 years. The prevalence of S. aureus remained unchanged in all children. Competitive associations were found between S. pneumoniae and S. aureus and between H. influenzae and S. aureus among children. In individuals >12 years, the prevalence of colonisation decreased from 11.2% to 6.8%, 16.7% to 8.8% and 31.2% to 23.7% for S. pneumoniae, H. influenzae and S. aureus, respectively; p < 0.001 for all comparions. Synergistic relationships for S. aureus with H. influenzae and S. pneumoniae were observed in both periods among this group.

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  • Shiri, T. (author)
  • Nunes, M. C. (author)
  • Klugman, K. P. (author)
  • Kahn, KathleenUmeå universitet,Epidemiologi och global hälsa,MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa ; INDEPTH Network, Accra, Ghana(Swepub:umu)kaka0045 (author)
  • Twine, R. (author)
  • de Gouveia, L. (author)
  • von Gottberg, A. (author)
  • Madhi, S. A. (author)
  • Umeå universitetEpidemiologi och global hälsa (creator_code:org_t)

Related titles

  • In:Vaccine: Elsevier32:42, s. 5520-55300264-410X1873-2518

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  • Vaccine (Search for host publication in LIBRIS)

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By the author/editor
Nzenze, S. A.
Shiri, T.
Nunes, M. C.
Klugman, K. P.
Kahn, Kathleen
Twine, R.
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de Gouveia, L.
von Gottberg, A.
Madhi, S. A.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Immunology in th ...
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Vaccine
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Umeå University

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Nzenze, S. A.
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