Sökning: id:"swepub:oai:DiVA.org:umu-96617" >
External Validity o...
-
Hagg, LovisaUmeå universitet,Medicin
(författare)
External Validity of the ARISTOTLE Trial in Real-Life Atrial Fibrillation Patients
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
-
2014-09-09
-
Wiley,2014
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-96617
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96617URI
-
https://doi.org/10.1111/1755-5922.12087DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
ObjectiveOur primary objective was to determine the proportion of patients with atrial fibrillation (AF) eligible for enrollment in a randomized controlled trial for a novel oral anticoagulant, the ARISTOTLE trial. A secondary objective was to describe the reasons for trial ineligibility.MethodsWe performed a cross-sectional study of an unselected population including 2274 patients in Skelleftea, Sweden with at least one verified episode of AF on or before December 31, 2010. Patients were classified as suitable or unsuitable for anticoagulant treatment according to current guidelines. The enrollment criteria from the ARISTOTLE trial were extracted from the original publication and applied to the population.ResultsAmong all patients with AF, 1579 were classified as suitable for anticoagulant treatment. Of these, only 658 patients (42%) were eligible for participation in the ARISTOTLE trial. Among the 921 patients ineligible for participation, 498 did not meet the ECG criteria, 272 had psychosocial problems, and in addition, 78 patients were excluded due to both of these criteria.ConclusionOur study shows that a majority of the patients in an unselected population with AF suitable for anticoagulant treatment were ineligible for participation in the ARISTOTLE trial. The applicability of the ARISTOTLE trial is therefore unknown for a considerable proportion of patients with AF in real life.
Ämnesord och genrebeteckningar
-
Apixaban
-
ARISTOTLE
-
Arrhythmias
-
Atrial fibrillation
-
Coagulation
-
Thrombosis
-
External validity
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Johansson, CeciliaUmeå universitet,Medicin
(författare)
-
Jansson, Jan-HåkanUmeå universitet,Medicin(Swepub:umu)jaja0006
(författare)
-
Johansson, LarsUmeå universitet,Medicin(Swepub:umu)lrsjon80
(författare)
-
Umeå universitetMedicin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Cardiovascular Therapeutics: Wiley32:5, s. 214-2181755-5914
Internetlänk
Hitta via bibliotek
Till lärosätets databas