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Impact of Age and G...
Impact of Age and Gender on the Prevalence and Prognostic Importance of the Metabolic Syndrome and Its Components in Europeans. The MORGAM Prospective Cohort Project
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Vishram, Julie K. K. (author)
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Borglykke, Anders (author)
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Andreasen, Anne H. (author)
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Jeppesen, Jorgen (author)
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Ibsen, Hans (author)
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Jorgensen, Torben (author)
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Palmieri, Luigi (author)
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Giampaoli, Simona (author)
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Donfrancesco, Chiara (author)
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Kee, Frank (author)
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Mancia, Giuseppe (author)
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Cesana, Giancarlo (author)
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Kuulasmaa, Kari (author)
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Salomaa, Veikko (author)
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Sans, Susana (author)
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Ferrieres, Jean (author)
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Dallongeville, Jean (author)
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
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Arveiler, Dominique (author)
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Wagner, Aline (author)
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Tunstall-Pedoe, Hugh (author)
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Drygas, Wojciech (author)
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Olsen, Michael H. (author)
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(creator_code:org_t)
- 2014-09-22
- 2014
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:9, s. e107294-
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS). Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19-78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5. Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P<0.0001); with a 5-fold increase in women from ages 19-39 years to 60-78 years (7.4%/7.6% to 35.4%/37.6% for IDF/NCEP-ATPIII) and a 2-fold increase in men (5.3%/10.5% to 11.5%/21.8%). Using multivariate-adjusted Cox regressions, the associations between MetS and all three CVD events were significant (P<0.0001). For IDF/NCEP-ATPIII in men and women, hazard ratio (HR) for CHD was 1.60/1.62 and 1.93/2.03, for CVD mortality 1.73/1.65 and 1.77/2.06, and for stroke 1.51/1.53 and 1.58/1.77. Whereas in men the HRs for CVD events were independent of age (MetS*age, P>0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS*age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS*age, P>0.05). Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Vishram, Julie K ...
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Borglykke, Ander ...
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Andreasen, Anne ...
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Jeppesen, Jorgen
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Ibsen, Hans
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Jorgensen, Torbe ...
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Palmieri, Luigi
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Giampaoli, Simon ...
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Donfrancesco, Ch ...
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Kee, Frank
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Mancia, Giuseppe
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Cesana, Giancarl ...
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Kuulasmaa, Kari
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Salomaa, Veikko
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Sans, Susana
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Ferrieres, Jean
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Dallongeville, J ...
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Söderberg, Stefa ...
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Arveiler, Domini ...
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Wagner, Aline
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Tunstall-Pedoe, ...
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Drygas, Wojciech
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Olsen, Michael H ...
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