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STC1 Expression By ...
STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
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- Pena, Cristina (author)
- Karolinska Institute, Sweden
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- Virtudes Cespedes, Maria (author)
- Centre Bioengn Biomat and Nanomed CIBER BBN, Spain
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- Bradic Lindh, Maja (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Kiflemariam, Sara (author)
- Uppsala universitet,Genomik,Uppsala University, Sweden
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- Mezheyeuski, Artur (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Edqvist, Per-Henrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi,Uppsala University, Sweden
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- Hägglöf, Christina (author)
- Karolinska Institutet, Stockholm, Sweden
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- Birgisson, Helgi (author)
- Uppsala universitet,Kolorektalkirurgi,Uppsala University, Sweden
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- Bojmar, Linda (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Sandström, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Kirurgiska kliniken US
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- Olsson, Eleonor (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Veerla, Srinivas (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Gallardo, Alberto (author)
- Centre Bioengn Biomat and Nanomed CIBER BBN, Spain
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- Sjöblom, Tobias (author)
- Uppsala universitet,Genomik,Uppsala University, Sweden
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- Chang, AndyC -M (author)
- University of Sydney, Australia
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- Reddel, Roger R. (author)
- University of Sydney, Australia
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- Mangues, Ramon (author)
- Centre Bioengn Biomat and Nanomed CIBER BBN, Spain
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- Augsten, Martin (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Ostman, Arne (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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(creator_code:org_t)
- American Association for Cancer Research, 2013
- 2013
- English.
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In: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 74:4, s. 1287-1297
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Pena, Cristina
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Virtudes Cespede ...
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Bradic Lindh, Ma ...
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Kiflemariam, Sar ...
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Mezheyeuski, Art ...
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Edqvist, Per-Hen ...
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show more...
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Hägglöf, Christi ...
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Birgisson, Helgi
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Bojmar, Linda
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Jirström, Karin
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Sandström, Per
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Olsson, Eleonor
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Veerla, Srinivas
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Gallardo, Albert ...
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Sjöblom, Tobias
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Chang, AndyC -M
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Reddel, Roger R.
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Mangues, Ramon
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Augsten, Martin
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Ostman, Arne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Research
- By the university
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Linköping University
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University