Somatic mutations affect key pathways in lung adenocarcinoma

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Ding, Li (author)

Somatic mutations affect key pathways in lung adenocarcinoma

Article/chapterEnglish2008

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Springer Science and Business Media LLC,2008
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LIBRIS-ID:oai:DiVA.org:uu-100853
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100853URI
https://doi.org/10.1038/nature07423DOI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. Here we report the results of a collaborative study to discover somatic mutations in 188 human lung adenocarcinomas. DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. The frequently mutated genes include tyrosine kinases, among them the EGFR homologue ERBB4; multiple ephrin receptor genes, notably EPHA3; vascular endothelial growth factor receptor KDR; and NTRK genes. These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment.

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MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Getz, Gad (author)
Wheeler, David A (author)
Mardis, Elaine R (author)
McLellan, Michael D (author)
Cibulskis, Kristian (author)
Sougnez, Carrie (author)
Greulich, Heidi (author)
Muzny, Donna M (author)
Morgan, Margaret B (author)
Fulton, Lucinda (author)
Fulton, Robert S (author)
Zhang, Qunyuan (author)
Wendl, Michael C (author)
Lawrence, Michael S (author)
Larson, David E (author)
Chen, Ken (author)
Dooling, David J (author)
Sabo, Aniko (author)
Hawes, Alicia C (author)
Shen, Hua (author)
Jhangiani, Shalini N (author)
Lewis, Lora R (author)
Hall, Otis (author)
Zhu, Yiming (author)
Mathew, Tittu (author)
Ren, Yanru (author)
Yao, Jiqiang (author)
Scherer, Steven E (author)
Clerc, Kerstin (author)
Metcalf, Ginger A (author)
Ng, Brian (author)
Milosavljevic, Aleksandar (author)
Gonzalez-Garay, Manuel L (author)
Osborne, John R (author)
Meyer, Rick (author)
Shi, Xiaoqi (author)
Tang, Yuzhu (author)
Koboldt, Daniel C (author)
Lin, Ling (author)
Abbott, Rachel (author)
Miner, Tracie L (author)
Pohl, Craig (author)
Fewell, Ginger (author)
Haipek, Carrie (author)
Schmidt, Heather (author)
Dunford-Shore, Brian H (author)
Kraja, Aldi (author)
Crosby, Seth D (author)
Sawyer, Christopher S (author)
Vickery, Tammi (author)
Sander, Sacha (author)
Robinson, Jody (author)
Winckler, Wendy (author)
Baldwin, Jennifer (author)
Chirieac, Lucian R (author)
Dutt, Amit (author)
Fennell, Tim (author)
Hanna, Megan (author)
Johnson, Bruce E (author)
Onofrio, Robert C (author)
Thomas, Roman K (author)
Tonon, Giovanni (author)
Weir, Barbara A (author)
Zhao, Xiaojun (author)
Ziaugra, Liuda (author)
Zody, Michael C.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)miczo266 (author)
Giordano, Thomas (author)
Orringer, Mark B (author)
Roth, Jack A (author)
Spitz, Margaret R (author)
Wistuba, Ignacio I (author)
Ozenberger, Bradley (author)
Good, Peter J (author)
Chang, Andrew C (author)
Beer, David G (author)
Watson, Mark A (author)
Ladanyi, Marc (author)
Broderick, Stephen (author)
Yoshizawa, Akihiko (author)
Travis, William D (author)
Pao, William (author)
Province, Michael A (author)
Weinstock, George M (author)
Varmus, Harold E (author)
Gabriel, Stacey B (author)
Lander, Eric S (author)
Gibbs, Richard A (author)
Meyerson, Matthew (author)
Wilson, Richard K (author)
Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

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In:Nature: Springer Science and Business Media LLC455:7216, s. 1069-10750028-08361476-4687

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By the author/editor: Ding, Li; Getz, Gad; Wheeler, David A; Mardis, Elaine R; McLellan, Michae ...; Cibulskis, Krist ...; show more...; Sougnez, Carrie; Greulich, Heidi; Muzny, Donna M; Morgan, Margaret ...; Fulton, Lucinda; Fulton, Robert S; Zhang, Qunyuan; Wendl, Michael C; Lawrence, Michae ...; Larson, David E; Chen, Ken; Dooling, David J; Sabo, Aniko; Hawes, Alicia C; Shen, Hua; Jhangiani, Shali ...; Lewis, Lora R; Hall, Otis; Zhu, Yiming; Mathew, Tittu; Ren, Yanru; Yao, Jiqiang; Scherer, Steven ...; Clerc, Kerstin; Metcalf, Ginger ...; Ng, Brian; Milosavljevic, A ...; Gonzalez-Garay, ...; Osborne, John R; Meyer, Rick; Shi, Xiaoqi; Tang, Yuzhu; Koboldt, Daniel ...; Lin, Ling; Abbott, Rachel; Miner, Tracie L; Pohl, Craig; Fewell, Ginger; Haipek, Carrie; Schmidt, Heather; Dunford-Shore, B ...; Kraja, Aldi; Crosby, Seth D; Sawyer, Christop ...; Vickery, Tammi; Sander, Sacha; Robinson, Jody; Winckler, Wendy; Baldwin, Jennife ...; Chirieac, Lucian ...; Dutt, Amit; Fennell, Tim; Hanna, Megan; Johnson, Bruce E; Onofrio, Robert ...; Thomas, Roman K; Tonon, Giovanni; Weir, Barbara A; Zhao, Xiaojun; Ziaugra, Liuda; Zody, Michael C.; Giordano, Thomas; Orringer, Mark B; Roth, Jack A; Spitz, Margaret ...; Wistuba, Ignacio ...; Ozenberger, Brad ...; Good, Peter J; Chang, Andrew C; Beer, David G; Watson, Mark A; Ladanyi, Marc; Broderick, Steph ...; Yoshizawa, Akihi ...; Travis, William ...; Pao, William; Province, Michae ...; Weinstock, Georg ...; Varmus, Harold E; Gabriel, Stacey ...; Lander, Eric S; Gibbs, Richard A; Meyerson, Matthe ...; Wilson, Richard ...; show less...

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