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  • Dutt, Amit (author)

Drug-sensitive FGFR2 mutations in endometrial carcinoma

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008-06-24
  • Proceedings of the National Academy of Sciences,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-100854
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100854URI
  • https://doi.org/10.1073/pnas.0803379105DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy. Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma. These FGFR2 mutations, many of which are identical to mutations associated with congenital craniofacial developmental disorders, are constitutively activated and oncogenic when ectopically expressed in NIH 3T3 cells. Inhibition of FGFR2 kinase activity in endometrial carcinoma cell lines bearing such FGFR2 mutations inhibits transformation and survival, implicating FGFR2 as a novel therapeutic target in endometrial carcinoma.

Subject headings and genre

  • endometrial cancer
  • fibroblast growth factor receptor 2
  • oncogene
  • targeted therapy
  • tyrosine kinase
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Salvesen, Helga B (author)
  • Chen, Tzu-Hsiu (author)
  • Ramos, Alex H (author)
  • Onofrio, Robert C (author)
  • Hatton, Charlie (author)
  • Nicoletti, Richard (author)
  • Winckler, Wendy (author)
  • Grewal, Rupinder (author)
  • Hanna, Megan (author)
  • Wyhs, Nicolas (author)
  • Ziaugra, Liuda (author)
  • Richter, Daniel J (author)
  • Trovik, Jone (author)
  • Engelsen, Ingeborg B (author)
  • Stefansson, Ingunn M (author)
  • Fennell, Tim (author)
  • Cibulskis, Kristian (author)
  • Zody, Michael C.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)miczo266 (author)
  • Akslen, Lars A (author)
  • Gabriel, Stacey (author)
  • Wong, Kwok-Kin (author)
  • Sellers, William R (author)
  • Meyerson, Matthew (author)
  • Greulich, Heidi (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences105:25, s. 8713-87170027-84241091-6490

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