Association between repeat length of exon 1 CAG microsatellite in the androgen receptor and bone density in men is modulated by sex hormone levels

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Stiger, FredrikUppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis (author)

Association between repeat length of exon 1 CAG microsatellite in the androgen receptor and bone density in men is modulated by sex hormone levels

Article/chapterEnglish2008

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2008-05-18
Springer Science and Business Media LLC,2008
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-101162
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101162URI
https://doi.org/10.1007/s00223-008-9128-3DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:117357051URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

In this study we examined whether the androgen receptor (AR) gene CAG repeat polymorphism and serum androgen levels are associated with bone mineral density (BMD) and changes in BMD during 2-3 years in 229 healthy men 41-76 years old. Microsatellite analysis was performed on an automated sequencer. Indices of bioavailable testosterone (free testosterone [FT] and free androgen index) were calculated. BMD was measured using both dual-energy Xray absorptiometry and quantitative ultrasound. All participants completed a questionnaire regarding major possible osteoporosis risk factors. In linear regression analysis there was a modest positive association, which was independent of age and body mass index (BMI), between AR repeat length and BMD at all sites. Although this association was significant independent of BMI, analyses in the subgroup of obese men (BMI > 30) did not reach significance, while the effect was enhanced when analyzing only nonobese men (BMI < or = 30). There was no association between the AR gene polymorphism and rate of bone loss, FT, and BMD or testosterone and bone loss. Interestingly, the association between AR and BMD was modified by total testosterone. The lowest age- and BMI-adjusted average femoral neck BMD was found among men in the lowest tertile for both AR repeat length and FT, whereas men within the higher categories of these variables displayed the highest BMD. In conclusion, there is a positive association between the AR CAG repeat polymorphism and BMD, which is modified by androgen levels in healthy men.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Androgen receptor
CAG microsatellite
Bone density
Sex hormone
Polymorphism
MEDICINE
MEDICIN
Orthopaedics
Ortopedi
Orthopaedics
Ortopedi

Added entries (persons, corporate bodies, meetings, titles ...)

Brändström, HelenaUppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases(Swepub:uu)helebran (author)
Gillberg, Peter (author)
Melhus, HåkanUppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis(Swepub:uu)hakamelh (author)
Wolk, AlicjaKarolinska Institutet (author)
Michaelsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich (author)
Kindmark, AndreasUppsala universitet,Institutionen för medicinska vetenskaper,Metabolic Bone Diseases(Swepub:uu)andrkind (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Calcified Tissue International: Springer Science and Business Media LLC82:6, s. 427-350171-967X1432-0827

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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By the university: Uppsala University; Karolinska Institutet

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