Sökning: WFRF:(Ingelsson Erik)
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Circulating retinol...
Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
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- Ingelsson, Erik (författare)
- Karolinska Institutet,Uppsala universitet,Geriatrik
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical pharmacogenetics and osteoporosis
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- Michaëlsson, Karl (författare)
- Uppsala universitet,Ortopedi
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- Berne, Christian (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Vasan, Ramachandran S. (författare)
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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Blomhoff, Rune (författare)
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Ärnlöv, Johan (författare)
- Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 206:1, s. 239-244
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Our aim was to examine relations of serum retinol-binding protein 4 (RBP4) to cardiovascular risk factors, and prevalent metabolic syndrome (MetS) and cardiovascular disease (CVD) in a large community-based sample of elderly. METHODS: We evaluated cross-sectional relations of serum RBP4 to cardiovascular risk factors including anthropometrical measures, blood pressure, lipid measures, fasting glucose and insulin, body fat distribution including truncal fat by dual-energy x-ray absorptiometry (DXA), homeostasis model assessment insulin resistance (HOMA-IR) and prevalent MetS in one thousand eight 70-year old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), and in five hundred seven 82-year old men from Uppsala Longitudinal Study of Adult Men (ULSAM). In ULSAM, we also examined associations with prevalent CVD. RESULTS: RBP4 concentrations were positively correlated with serum triglycerides (r=0.30; P<0.0001 in both samples), whereas correlations with body mass index (BMI), waist circumference, sagittal abdominal diameter, total and truncal fat mass, total cholesterol, fasting glucose and HOMA-IR were weak. In multivariable-adjusted models, RBP-4 was associated with MetS (odds ratio (OR), 1.16 and 1.33; 95% confidence interval (CI), 0.99-1.37 and 1.05-1.67 per 1-standard deviation (SD) increase in PIVUS and ULSAM, respectively), and prior cerebrovascular disease (OR, 1.37; 95% CI, 1.00-1.88 per 1-SD increase in ULSAM), but not with prior myocardial infarction. CONCLUSION: In elderly, RBP4 concentrations were associated with MetS and its components in both sexes, and prior cerebrovascular disease in men. These findings are consistent with the hypothesis that circulating RBP4 could be a marker of metabolic complications and possibly also atherosclerosis and overt CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Adipokines
- Obesity
- Cardiovascular disease
- Atherosclerosis
- Metabolic syndrome
- MEDICINE
- MEDICIN
- Orthopaedics
- Ortopedi
- Hälsa och välfärd
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ingelsson, Erik
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Sundström, Johan
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Melhus, Håkan
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Michaëlsson, Kar ...
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Berne, Christian
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Vasan, Ramachand ...
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visa fler...
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Risérus, Ulf
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Blomhoff, Rune
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Lind, Lars
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Ärnlöv, Johan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Atherosclerosis
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet
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Högskolan Dalarna