Antimicrobial triterpenes from Poulsenia armata Miq. Standl.

• Crude petroleum ether extract from the bark of Poulsenia armata showed antimicrobial activity. Activity-guided fractionation led to the isolation and structure elucidation of two active new triterpene derivatives, the stearate of glut-5-en-3beta-ol (1) and 3beta,28-diacetoxyurs-12-ene (4), for the first time as naturally occurring compounds. Compound 4 has previously been synthesized. The structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry and chemical transformations. This is the first report on the chemistry and pharmacology of the genus.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Nyckelord

Poulsenia arinata

Moraceae

triterpenes

antimicrobial activity

accelerating gradient

chromatography

NMR and NIS spectrometry

PHARMACY

FARMACI

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)