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Sökning: WFRF:(Baecklund Eva) > (2005-2009) > Anti-tumour necrosi...

Anti-tumour necrosis factor therapy in rheumatoid arthritis and risk of malignant lymphomas : relative risks and time trends in the Swedish Biologics Register

Askling, Johan (författare)
Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Baecklund, Eva (författare)
Uppsala University,Uppsala universitet,Reumatologi,Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
Granath, F. (författare)
Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
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Geborek, Pierre (författare)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Department of Rheumatology, Lund University Hospital, Lund, Sweden
Fored, M. (författare)
Karolinska Institutet,Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Backlin, Carin (författare)
Karolinska Institutet,Uppsala universitet,Institutionen för genetik och patologi,Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden
Bertilsson, L. (författare)
University of Gothenburg,Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden
Cöster, Lars (författare)
Östergötlands Läns Landsting,Linköpings universitet,Linköping University,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland,Department of Rheumatology, Linköping University Hospital, Linköping, Sweden
Jacobsson, L. T. (författare)
Lund University,Department of Rheumatology, Malmö University Hospital, Malmö, Sweden,Department of Rheumatology, Falu County Hospital, Falun, Sweden
Lindblad, S. (författare)
Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Lysholm, J. (författare)
Rantapää-Dahlqvist, Solbritt (författare)
Umeå universitet,Umeå University,Umeå University Hospital, Umeå, Sweden,Reumatologi
Saxne, Tore (författare)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Department of Rheumatology, Lund University Hospital, Lund, Sweden
van Vollenhoven, R. (författare)
Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Klareskog, L. (författare)
Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
Feltelius, N. (författare)
Karolinska Institutet,Medical Products Agency, Uppsala, Sweden
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 (creator_code:org_t)
2008-05-08
2009
Engelska.
Ingår i: Annals of the Rheumatic Diseases. - London, UK : BMJ. - 0003-4967 .- 1468-2060. ; 68:5, s. 648-653
Relaterad länk:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
https://urn.kb.se/re...
http://kipublication...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND:Tumour necrosis factor (TNF) antagonists have proved effective as treatment against rheumatoid arthritis (RA), but the unresolved issue of whether the use of anti-TNF therapy increases the already elevated risk of lymphoma in RA remains a concern.METHODS:Using the Swedish Biologics Register (ARTIS), the Swedish Cancer Register, pre-existing RA cohorts and cross-linkage with other national health and census registers, a national RA cohort (n = 67,743) was assembled and patients who started anti-TNF therapy between 1998 and July 2006 (n = 6604) were identified. A general population comparator (n = 471,024) was also assembled and the incidence of lymphomas from 1999 to 31 December 2006 was assessed and compared in these individuals.RESULTS:Among the 6604 anti-TNF-treated RA patients, 26 malignant lymphomas were observed during 26,981 person-years of follow-up, which corresponded to a relative risk (RR) of 1.35 (95% CI 0.82 to 2.11) versus anti-TNF-naive RA patients (336 lymphomas during 365,026 person-years) and 2.72 (95% CI 1.82 to 4.08) versus the general population comparator (1568 lymphomas during 3,355,849 person-years). RA patients starting anti-TNF therapy in 1998-2001 accounted for the entire increase in lymphoma risk versus the two comparators. By contrast, RR did not vary significantly by time since start of first treatment or with the accumulated duration of treatment, nor with the type of anti-TNF agent.CONCLUSION:Overall and as used in routine care against RA, TNF antagonists are not associated with any major further increase in the already elevated lymphoma occurrence in RA. Changes in the selection of patients for treatment may influence the observed risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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MEDICINE
MEDICIN

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