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  • Orozco, Gisela (author)

Association of STAT4 with rheumatoid arthritis : a replication study in three European populations

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Wiley,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-102296
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102296URI
  • https://doi.org/10.1002/art.23549DOI
  • https://lup.lub.lu.se/record/1257138URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: This study was undertaken to investigate the previously reported association of the STAT4 polymorphism rs7574865 with rheumatoid arthritis (RA) in 3 different European populations from Spain, Sweden, and The Netherlands, comprising a total of 2,072 patients and 2,474 controls. METHODS: Three different cohorts were included in the study: 923 RA patients and 1,296 healthy controls from Spain, 273 RA patients and 285 healthy controls from Sweden, and 876 RA patients and 893 healthy controls from The Netherlands. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the STAT4 single-nucleotide polymorphism rs7574865 using a TaqMan 5'-allele discrimination assay. The chi-square test was performed to compare allele and genotype distributions. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. RESULTS: We observed a significantly increased frequency of the minor T allele in RA patients compared with healthy controls in the Spanish population (24.8% versus 20.8%; P = 0.001, OR 1.26 [95% CI 1.09-1.45]). This association was confirmed in both the Swedish population (P = 0.03, OR 1.35 [95% CI 1.03-1.77]) and the Dutch population (P = 0.03, OR 1.45 [95% CI 1.21-1.73]). The overall P value for all 3 populations was 9.79 x 10(-6) (OR 1.25 [95% CI 1.13-1.37]). No association between rs7574865 and the presence of rheumatoid factor or anti-cyclic citrullinated peptide autoantibodies was observed. A meta-analysis of all published STAT4 associations revealed an OR of 1.25 (95% CI 1.19-1.33) (P = 1 x 10(-5)). CONCLUSION: Our findings indicate an association between the STAT4 polymorphism rs7574865 and RA in 3 different populations, from Spain, Sweden, and The Netherlands, thereby confirming previous data.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Alizadeh, Behrooz Z. (author)
  • Delgado-Vega, Angélica M.Uppsala universitet,Institutionen för genetik och patologi (author)
  • González-Gay, Miguel A. (author)
  • Balsa, Alejandro (author)
  • Pascual-Salcedo, Dora (author)
  • Fernández-Gutierrez, Benjamín (author)
  • González-Escribano, María F. (author)
  • Petersson, IngemarLund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)ort-ipe (author)
  • van Riel, Piet L. C. M. (author)
  • Barrera, Pilar (author)
  • Coenen, Marieke J. H. (author)
  • Radstake, Timothy R. D. J. (author)
  • van Leeuwen, Miek A. (author)
  • Wijmenga, Cisca (author)
  • Koeleman, Bobby P. C. (author)
  • Alarcón-Riquelme, MartaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)martaala (author)
  • Martín, Javier (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Arthritis and Rheumatism: Wiley58:7, s. 1974-19800004-35911529-0131

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