A single nucleotide polymorphism in the promoter region of the human gene for osteoprotegerin is related to vascular morphology and function

Brändström, HelenaUppsala universitet,Institutionen för medicinska vetenskaper (författare)

Osteoprotegerin (OPG) is a secreted member of the tumor necrosis factor receptor family, and has previously been shown to regulate bone mass by inhibiting osteoclast differentiation and activation. Recent evidence indicates that OPG also plays a role in the vascular system, since ablation of the OPG gene in mice results in calcification of the aorta and renal arteries, and association has been found between serum levels of OPG and cardiovascular mortality. This study presents a novel single nucleotide polymorphism, a T/C transition located 129 bp upstream the TATA-box of the human OPG gene, detected by sequence analysis. The OPG genotype was determined by restriction fragment length polymorphism in a cohort consisting of 59 healthy subjects. The intima-media thickness (IMT) in the common carotid artery and maximal post-ischemic forearm blood flow (FBF) were investigated. Subjects with the CC genotype showed a significantly increased IMT (p<0.05) and a concommitantly reduced maximal FBF (p<0.01) as compared to those with the T allele. Thus, our results show that the polymorphism in the promoter region of OPG is associated with both vascular morphology and function in apparently healthy subjects.

Stiger, FredrikUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)fredstig (författare)
Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)larslind (författare)
Kahan, ThomasKarolinska Institutet (författare)
Melhus, HåkanUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)hakamelh (författare)
Kindmark, AndreasUppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin(Swepub:uu)andrkind (författare)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:Biochemical and Biophysical Research Communications - BBRC293:1, s. 13-170006-291X1090-2104

Av författaren/redakt...: Brändström, Hele ...; Stiger, Fredrik; Lind, Lars; Kahan, Thomas; Melhus, Håkan; Kindmark, Andrea ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.