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Adiponectin and per...
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Li, XiaonanUmeå universitet,Pediatrik,Dept. of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden
(författare)
Adiponectin and peroxisome proliferator-activated receptor gamma expression in subcutaneous and omental adipose tissue in children
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Wiley,2008
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-103463
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103463URI
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https://doi.org/10.1111/j.1651-2227.2008.00715.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10171URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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AIM: To compare the expression levels of the adiponectin and peroxisome proliferator -activated receptor gamma (PPARgamma) genes in subcutaneous adipose tissue (SC) and omental adipose tissue (OM) in children with relation to age and anthropometric variables. METHODS: Paired biopsies (SC and OM) were obtained from 53 children (age 0.2-14 years, BMI 12.5-25.8 kg/m(2)). Adiponectin and PPARgamma mRNA levels in adipose tissue were measured by real-time PCR. RESULTS: In overweight, but not in normal weight children, the median adiponectin mRNA level was significantly lower in OM [0.51 (0.1-2.17)] compared to SC [1.29 (0.16-5.08)], (p = 0.03). Adiponectin mRNA levels were strongly associated with PPARgamma mRNA levels in both SC (r = 0.73, p < 0.001) and OM (r = 0.78, p < 0.001). CONCLUSIONS: The lower adiponectin expression in OM relative to SC in overweight children indicates that metabolic-endocrine alterations begin already in childhood. The close association between adiponectin and PPARgamma expression supports the hypothesis this transcription factor is involved in adiponectin gene regulation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindquist, SusanneUmeå universitet,Pediatrik(Swepub:umu)suli0001
(författare)
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Angsten, GertrudUmeå universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnkirurgi/ Christofferson,Pediatrik(Swepub:uu)gertmagn
(författare)
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Yi, Jun
(författare)
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Olsson, Tommy
(författare)
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Hernell, OlleUmeå universitet,Pediatrik(Swepub:umu)olhe0002
(författare)
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Umeå universitetPediatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Paediatrica: Wiley97:5, s. 630-50803-52531651-2227
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