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  • Irving, Gerd FaxénKarolinska Institutet (author)

Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease : the omega-3 Alzheimer's disease study

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Wiley,2009
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-103475
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103475URI
  • https://doi.org/10.1111/j.1532-5415.2008.02055.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74160URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118085584URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Funding Agencies:Funds of CapioSwedish Alzheimer Foundation Odd FellowSwedish Society of Physicians  Lion's Sweden 
  • OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.

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  • Freund-Levi, Yvonne,1956-Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden(Swepub:oru)yfi (author)
  • Eriksdotter-Jönhagen, MariaKarolinska Institutet (author)
  • Basun, HansUppsala universitet,Geriatrik,Divisions of Geriatrics, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)habas169 (author)
  • Brismar, KerstinKarolinska Institutet (author)
  • Hjorth, ErikKarolinska Institutet (author)
  • Palmblad, JanKarolinska Institutet (author)
  • Vessby, BengtUppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)bengvess (author)
  • Vedin, IngerKarolinska Institutet (author)
  • Wahlund, Lars-OlofKarolinska Institutet (author)
  • Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Department of Medicine, Karolinska University, Hospital, Huddinge, Stockholm, Sweden(Swepub:uu)tomce419 (author)
  • Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Journal of The American Geriatrics Society: Wiley57:1, s. 11-170002-86141532-5415

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