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Omega-3 fatty acid ...
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Irving, Gerd FaxénKarolinska Institutet
(author)
Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease : the omega-3 Alzheimer's disease study
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Wiley,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-103475
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103475URI
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https://doi.org/10.1111/j.1532-5415.2008.02055.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74160URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118085584URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Funds of CapioSwedish Alzheimer Foundation Odd FellowSwedish Society of Physicians Lion's Sweden
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OBJECTIVES: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer's disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4). DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Specialist memory clinics in the Stockholm catchment area. PARTICIPANTS: Two hundred four patients (aged 73+/-9, 52% women) with mild to moderate AD. INTERVENTION: Patients with AD received 1.7 g of docosahexaenoic acid (DHA) and 0.6 g of eicosapentaenoic acid (EPA) (Omega-3/Omega-3 group; n=89, aged 73+/-9, 57% women) or placebo 0.6 g of linoleic acid per day (placebo/Omega-3 group; n=85, aged 73+/-9, 46% women) for 6 months. After 6 months, all patients received DHA and EPA for another 6 months. MEASUREMENTS: Anthropometry, biochemical nutritional and inflammatory markers, and appetite assessed by caregiver. RESULTS: Mean weight and body mass index (kg/m(2)) at baseline were 70.0+/-11.8 kg and 24.3+/-3.0 kg/m(2), respectively. At 6- and 12-month follow-up, weight had increased 0.7+/-2.5 kg (P=.02) and 1.4+/-2.9 kg (P<.001) in the Omega-3/Omega-3 group. In the placebo group, weight was unchanged at 6 months but had increased (P=.01) at 12 months follow-up after Omega-3 supplementation was initiated. Appetite improved in the Omega-3/Omega-3 group over the treatment period (P=.01). In logistic regression analyses, not carrying the APOEepsilon4 allele and high plasma DHA concentrations were independently related to weight gain in the combined group of patients at 6 months follow-up. CONCLUSION: A DHA-enriched Omega-3 FA supplement may positively affect weight and appetite in patients with mild to moderate AD. Not carrying the APOEepsilon4 allele and high DHA were independently associated with weight gain.
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Freund-Levi, Yvonne,1956-Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden(Swepub:oru)yfi
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Eriksdotter-Jönhagen, MariaKarolinska Institutet
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Basun, HansUppsala universitet,Geriatrik,Divisions of Geriatrics, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)habas169
(author)
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Brismar, KerstinKarolinska Institutet
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Hjorth, ErikKarolinska Institutet
(author)
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Palmblad, JanKarolinska Institutet
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Vessby, BengtUppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)bengvess
(author)
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Vedin, IngerKarolinska Institutet
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Wahlund, Lars-OlofKarolinska Institutet
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Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism,Department of Medicine, Karolinska University, Hospital, Huddinge, Stockholm, Sweden(Swepub:uu)tomce419
(author)
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Karolinska InstitutetDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
(creator_code:org_t)
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In:Journal of The American Geriatrics Society: Wiley57:1, s. 11-170002-86141532-5415
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Irving, Gerd Fax ...
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Freund-Levi, Yvo ...
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Eriksdotter-Jönh ...
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Basun, Hans
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Brismar, Kerstin
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Hjorth, Erik
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Palmblad, Jan
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Vessby, Bengt
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Vedin, Inger
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Cederholm, Tommy
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