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Serum cystatin C an...
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Sundelöf, JohanUppsala universitet,Geriatrik
(author)
Serum cystatin C and the risk of Alzheimer disease in elderly men
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-09-29
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Ovid Technologies (Wolters Kluwer Health),2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-103489
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103489URI
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https://doi.org/10.1212/01.wnl.0000326894.40353.93DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-3494URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD). METHODS: Serum cystatin C levels were analyzed at two examinations of the Uppsala Longitudinal Study of Adult Men, a longitudinal, community-based study of elderly men (age 70 years, n = 1,153 and age 77 years, n = 761, a subset of the age 70 examination). Cox regressions were used to examine associations between serum cystatin C and incident AD. AD cases were identified by cognitive screening and comprehensive medical chart review in all subjects. RESULTS: On follow-up (median 11.3 years), 82 subjects developed AD. At age 70 years, lower cystatin C was associated with higher risk of AD independently of age, APOE4 genotype, glomerular filtration rate, diabetes, hypertension, stroke, cholesterol, body mass index, smoking, education level, and plasma amyloid-beta protein 40 and 42 levels (hazard ratio [HR] for lowest [<1.12 micromol/L] vs highest [>1.30 micromol/L] tertile = 2.67, 95% CI 1.22-5.83, p < 0.02). The results were similar at age 77 years (43 participants developed AD during follow-up). Furthermore, a 0.1-mumol/L decrease of cystatin C between ages 70 and 77 years was associated with a 29% higher risk of incident AD (HR 1.29, 95% CI 1.03-1.63, p < 0.03). CONCLUSIONS: Low levels of serum cystatin C precede clinically manifest Alzheimer disease (AD) in elderly men free of dementia at baseline and may be a marker of future risk of AD. These findings strengthen the evidence for a role for cystatin C in the development of clinical AD.
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Ärnlöv, JohanHögskolan Dalarna,Medicinsk vetenskap(Swepub:du)jan
(author)
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Ingelsson, E.
(author)
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Sundström, J.Uppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)johasund
(author)
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Basu, SamarUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)samabasu
(author)
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Zethelius, BjörnUppsala universitet,Geriatrik(Swepub:uu)bjorzeth
(author)
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Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss
(author)
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Irizarry, M. C.
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik(Swepub:uu)vigie517
(author)
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Rönnemaa, ElinaUppsala universitet,Geriatrik(Swepub:uu)eliro837
(author)
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Degerman-Gunnarsson, MalinUppsala universitet,Geriatrik
(author)
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Hyman, B. T.
(author)
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Basun, HansUppsala universitet,Geriatrik(Swepub:uu)habas169
(author)
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Kilander, LenaUppsala universitet,Geriatrik(Swepub:uu)lekil226
(author)
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Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(author)
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Uppsala universitetGeriatrik
(creator_code:org_t)
Related titles
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In:Neurology: Ovid Technologies (Wolters Kluwer Health)71:14, s. 1072-10790028-38781526-632X
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Sundelöf, Johan
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Ärnlöv, Johan
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Ingelsson, E.
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Sundström, J.
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Basu, Samar
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Zethelius, Björn
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Larsson, Anders
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Irizarry, M. C.
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Giedraitis, Vilm ...
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Rönnemaa, Elina
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Degerman-Gunnars ...
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Hyman, B. T.
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Basun, Hans
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Kilander, Lena
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Lannfelt, Lars
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Högskolan Dalarna