Niacin skin-flush response and electrodermal activity in patients with schizophrenia and healthy controls

Nilsson, BjörnUppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset,Institutionen för neurovetenskap,Psykiatri, Ulleråker (författare)

Patients with schizophrenia have in different studies shown reduced niacin sensitivity and lower electrodermal activity (EDA) after auditory stimulation. Peripheral mediation of prostaglandins may have a physiological role in both responses. This motivates study of both niacin response and electrodermal responding in the same patients with schizophrenia. Thirty patients with schizophrenia and 17 controls were investigated with EDA and thereafter given 200 mg niacin orally with continuous assessment of skin temperature. The patients showed a delayed temperature increase after niacin ingestion (P = 0.002) and a higher frequency of electrodermal non-responding (P < 0.05). Response/non-response for niacin correlated with EDA response/non-response in the patient group (P = 0.009). The niacin test revealed a slower vasodilation reaction in the patients. The association between response patterns for the niacin test and EDA suggests that a common aberration in skin physiology may be of importance for both reactions in schizophrenia.

Hultman, ChristinaUppsala universitet,Karolinska Institutet,Institutionen för neurovetenskap,Psykiatri, Ulleråker(Swepub:uu)chrihult (författare)
Wiesel, Frits-AxelUppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset,Institutionen för neurovetenskap,Psykiatri, Ulleråker(Swepub:uu)fritwies (författare)
Uppsala universitetPsykiatri, Ulleråker, Akademiska sjukhuset (creator_code:org_t)

Ingår i:Prostaglandins, Leukotrienes and Essential Fatty Acids: Elsevier BV74, s. 339-3460952-32781532-2823
Ingår i:Prostaglandins, Leukotrines and Essential Fatty Acids: Elsevier BV74, s. 339-346

Av författaren/redakt...: Nilsson, Björn; Hultman, Christi ...; Wiesel, Frits-Ax ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.