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  • Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset (author)

Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects : --the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2007-11-15
  • Wiley,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-103761
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103761URI
  • https://doi.org/10.1007/s11745-007-3125-6DOI
  • https://research.chalmers.se/publication/100676URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The aim of the present study was to relate brachial artery intima-media thickness (IMT) and the grey scale median of the intima-media complex (IM-GSM) to traditional cardiovascular risk factors and markers of inflammation and oxidative stress. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population-based study of 1016 subjects aged 70, brachial artery IMT and IM-GSM, who were evaluated by ultrasound. Lipids, thirteen markers of inflammation and nine markers of oxidative stress were measured. The Framingham risk score was related to IMT (p < 0.0001), but not to the IM-GSM. In univariate analysis, HDL-cholesterol, serum triglycerides, fasting glucose, smoking, HOMA insulin resistance index and oxidized LDL levels were related to IMT. HDL and LDL-cholesterol, triglycerides, VCAM-1, e-selectin, leukocyte count, conjugated diens, baseline conjugated diens (BCD)-LDL, antibodies to oxLDL, the GSSG/GSH glutathione ratio and homocysteine were related to IM-GSM. In multiple regression models, HDL-cholesterol, fasting glucose and oxLDL levels were the independently related to IMT (p = 0.01-0.04), while serum triglycerides, BCD-LDL and the GSSG/GSH ratio were independently related to IM-GSM (p = 0.0001-0.004). In conclusion, in addition to traditional lipid variables, markers of oxidative stress were associated with both thickness and echogenicity of the brachial artery intima-media complex. Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future.

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  • Andersson, JessikaUppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset (author)
  • Rönn, MonikaAkademiska Sjukhuset (author)
  • Gustavsson, Tomas,1954Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gustav (author)
  • Holdfelt, PeterChalmers tekniska högskola,Chalmers University of Technology (author)
  • Hulthe, Johannes (author)
  • Elmgren, AndersAstraZeneca AB (author)
  • Zilmer, KerstiTartu Ülikool,University of Tartu (author)
  • Zilmer, MihkelTartu Ülikool,University of Tartu (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Lipids: Wiley43:2, s. 133-410024-42011558-9307

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