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Renal dysfunction a...
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Fellström, Bengt,1947-Uppsala universitet,Institutionen för medicinska vetenskaper,Njurmedicin, The ALERT trial
(author)
Renal dysfunction as a risk factor for mortality and cardiovascular disease in renal transplantation : experience from the Assessment of Lescol in Renal Transplantation trial
- Article/chapterEnglish2005
Publisher, publication year, extent ...
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Lippincott, Williams and Wilkins,2005
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-104290
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104290URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Renal-transplant recipients have shortened life expectancy primarily because of premature cardiovascular disease. Traditional and nontraditional risk factors for cardiovascular disease are prevalent in renal patients. In renal-transplant recipients, immunosuppressive therapy can be nephrotoxic and aggravate cardiovascular disease risk factors. Renal dysfunction has been established as a risk factor for cardiovascular disease and mortality in different populations. We evaluated the effects of baseline renal-transplant function on mortality and cardiovascular and renal endpoints in 1,052 placebo-treated patients of the Assessment of Lescol in Renal Transplantation trial. METHODS: All renal-transplant recipients were on cyclosporine-based immunosuppressive therapy. Follow-up was 5 to 6 years, and endpoints included cardiac death, noncardiovascular death, all-cause mortality, major adverse cardiac event (MACE), stroke, nonfatal myocardial infarction, and graft loss. RESULTS: Baseline serum creatinine was strongly and independently associated with increased cardiac, noncardiovascular, and all-cause mortality, as well as MACE and graft loss. Serum creatinine was not a risk factor for stroke or nonfatal myocardial infarction. CONCLUSIONS: Elevated baseline serum creatinine in renal-transplant recipients is a strong and independent risk factor for all-cause, noncardiovascular and cardiac mortality, MACE, and graft loss.
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Jardine, Alan G.The ALERT Trial
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Soveri, IngaUppsala universitet,Institutionen för medicinska vetenskaper,Njurmedicin, The ALERT Trial(Swepub:uu)insov254
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Cole, EdwardThe ALERT Trial
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Grönhagen-Riska, CarolaThe ALERT Trial
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Neumayer, Hans H.The ALERT Trial
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Maes, BartThe ALERT Trial
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Gimpelewicz, ClaudioThe ALERT Trial
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Holdaas, HallvardThe ALERT Trial
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Transplantation: Lippincott, Williams and Wilkins79:9, s. 1160-11630041-13371534-6080
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