Gender-associated risk factors for cardiac end points and total mortality after renal transplantation: post hoc analysis of the ALERT study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Oien Cecilia) > (2006) > Gender-associated r...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Oien, Cecilia MontgomeryThe ALERT Study Group (author)

Gender-associated risk factors for cardiac end points and total mortality after renal transplantation : post hoc analysis of the ALERT study

Article/chapterEnglish2006

Publisher, publication year, extent ...

Wiley,2006
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-104719
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104719URI
https://doi.org/10.1111/j.1399-0012.2006.00496.xDOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

BACKGROUND: Female gender offers a cardioprotective effect over men in the general population, but is lost in the dialysis population. Whether renal transplantation restores the gender-dependent cardiac protection and whether there is a difference in the impact of risk factors is not known. METHODS: This is a post hoc analysis of pre-defined end points in the placebo arm in the Assessment of Lescol in Renal Transplantation (ALERT) study, a study in renal transplant recipients. Cox regression was performed to estimate the association between different risk factors at baseline and non-fatal myocardial infarction (MI) or cardiac death and total mortality, and specifically assess whether there are gender differences. RESULTS: The placebo arm included 1052 patients (mean age 50.1 +/- 11.1 yr, 65.3% males) with a mean follow-up of 65 months. The incidence of non-fatal MI or cardiac death was 10.9% vs. 7.9% (NS) and total mortality 13.3% vs. 12.8% (NS) in men and women. In multivariate analysis, previous coronary heart disease (CHD), diabetes, treatment for rejection and serum triglycerides were predictive for cardiac events in men, and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio only in women. A slightly different risk-factor pattern appeared for total mortality. Diabetes, ECG abnormalities, plasma triglycerides, serum creatinine, time on dialysis and age predicted total mortality in men, while ECG abnormalities, LDL/HDL ratio and age were predictors in women. CONCLUSION: In this relatively low-risk population of renal transplant recipients, no gender difference in cardiac events or total mortality was observed, suggesting that female gender advantage regarding CHD is not restored following transplantation. The predictive value of risk factors differed in men and women.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
cardiovascular disease
gender
mortality
renal transplantation
risk factor analysis
Kidney diseases
Njursjukdomar
Medicine
medicin

Added entries (persons, corporate bodies, meetings, titles ...)

Reisaeter, Anna VarbergThe ALERT Study Group (author)
Os, IngridThe ALERT Study Group (author)
Jardine, AlanThe ALERT Study Group (author)
Fellström, Bengt,1947-Uppsala universitet,Institutionen för medicinska vetenskaper,The ALERT Study Group (author)
Holdaas, HallvardThe ALERT Study Group (author)
The ALERT Study GroupInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

In:Clinical Transplantation: Wiley20:3, s. 374-820902-00631399-0012

Internet link

Find in a library

Clinical Transplantation (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Oien, Cecilia Mo ...; Reisaeter, Anna ...; Os, Ingrid; Jardine, Alan; Fellström, Bengt ...; Holdaas, Hallvar ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

Articles in the publication: Clinical Transpl ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se