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Antigliadin immunog...
Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age
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- Lagerqvist, Carina (författare)
- Umeå universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Pediatrik
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- Dahlbom, Ingrid (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Norvall
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- Hansson, Tony (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediaditrisk forskning/Nordavall
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- Jidell, Erik, 1955- (författare)
- Umeå universitet,Klinisk immunologi
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- Juto, Per (författare)
- Umeå universitet,Virologi
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Olcén, Per (författare)
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- Stenlund, Hans (författare)
- Umeå universitet,Epidemiologi och folkhälsovetenskap
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- Hernell, Olle (författare)
- Umeå universitet,Pediatrik
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- Ivarsson, Anneli (författare)
- Umeå universitet,Epidemiologi och folkhälsovetenskap
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - 0277-2116 .- 1536-4801. ; 47:4, s. 428-35
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: The aim was to investigate age-dependent serum levels and occurrence of elevated celiac disease (CD)-related antibodies in young children, to define the optimal serological procedure when selecting for small intestinal biopsy. PATIENTS AND METHODS: Included were 428 children with biopsy verified CD (median age 16 months; range 7.5 months-14 years) and 216 controls (median age 2.7 years; range 8.5 months-14.6 years). Immunoglobulin (Ig) A antibodies against gliadin (AGA-IgA), tissue transglutaminase (tTG-IgA), and endomysium (EMA-IgA) were analysed. RESULTS: Increased serum AGA-IgA levels were found in 411 of 428 CD cases, tTG-IgA in 385 of 428, and EMA-IgA in 383 of 428. In the control group, 11 of 216 had increased levels of AGA-IgA, 5 of 216 of tTG-IgA, and 8 of 216 of EMA-IgA. In CD children younger than 18 months, elevated AGA-IgA occurred in 97% and elevated tTG-IgA and EMA-IgA were found in 83% of the cases. Conversely, in CD children older than 18 months, elevated AGA-IgA occurred in 94%, and elevated tTG-IgA and EMA-IgA were found in 99% of the cases. CONCLUSIONS: In children older than 18 months, both tTG-IgA and EMA-IgA are sufficiently accurate to be used as a single antibody marker, whereas a large proportion of younger children with CD lack these antibodies. Therefore, when selecting children for small intestinal biopsy, the detection of a combination of AGA-IgA and tTG-IgA is optimal for identifying untreated CD in children younger than 18 months.
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- MEDICINE
- MEDICIN
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Lagerqvist, Cari ...
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Dahlbom, Ingrid
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Hansson, Tony
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Jidell, Erik, 19 ...
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Juto, Per
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Olcén, Per
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Stenlund, Hans
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Hernell, Olle
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Ivarsson, Anneli
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Uppsala universitet
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Umeå universitet