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- Weis, JanUppsala universitet,Enheten för radiologi,Ahlström, H (author)
Two-dimensional spectroscopic imaging for pretreatment evaluation of prostate cancer : comparison with the step-section histology after radical prostatectomy
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- Elsevier BV,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-105201
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105201URI
- https://doi.org/10.1016/j.mri.2008.05.010DOI
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- Language:English
- Summary in:English
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- SwePubSwePub
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- PURPOSE: To minimize user and vendor dependence of the spectrum processing of prostate spectra, to measure the ratio of choline (Cho) plus creatine (Cr) to citrate (Cit) in the prostate tissue of normal volunteers and cancer patients, and to compare the results with pathologic findings after radical prostatectomy. MATERIALS AND METHODS: Four healthy volunteers and 13 patients with prostate cancer were measured. Measurements were performed using two-dimensional magnetic resonance spectroscopic imaging (MRSI) and endorectal coil. A standard vendor's spectrum processing approach has been modified. An original feature of this methodology was the combination of vendor-optimized and user-independent spectrum preprocessing in the scanner and user-independent quantitation in the environment of an MRUI software package. (Cho+Cr)/Cit ratio was used for the classification of prostate tissue. Results were compared with histopathology after radical prostatectomy. RESULTS: Eight of 13 cancer patients were classified as suspicious or very suspicious for cancer at spectroscopy, three were ambiguous for cancer and two patients were evaluated as false negative. A considerable overlap of metabolite ratios at various Gleason score was found. CONCLUSION: The proposed spectrum processing has the potential to improve the accuracy and user independency of the (Cho+Cr)/Cit quantitation. This study confirmed the previous results that a considerable overlap of (Cho+Cr)/Cit ratios exists at various Gleason score levels.
Subject headings and genre
- Prostate cancer
- Magnetic resonance spectroscopic imaging
- Radical prostatectomy
- Spectrum processing
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Ahlström, Håkan,1953-Uppsala universitet,Enheten för radiologi,Ahlström, H(Swepub:uu)hakanahl (author)
- Hlavcak, PeterUppsala universitet,Institutionen för genetik och patologi (author)
- Häggman, MikaelUppsala universitet,Urologkirurgi (author)
- Ortiz-Nieto, FranciscoUppsala universitet,Enheten för radiologi,Ahlström, H(Swepub:uu)fraor613 (author)
- Bergman, Antonina,1956-Uppsala universitet,Enheten för radiologi(Swepub:uu)abe03125 (author)
- Uppsala universitetEnheten för radiologi (creator_code:org_t)
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- In:Magnetic Resonance Imaging: Elsevier BV27:1, s. 87-930730-725X1873-5894
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