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Basal cytokeratins ...
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Eerola, Hannaleena
(author)
Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-02-14
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Springer Science and Business Media LLC,2008
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-105402
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105402URI
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https://doi.org/10.1186/bcr1863DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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INTRODUCTION: Finding new immunohistochemical markers that are specific to hereditary breast cancer could help us to select candidates for BRCA1/BRCA2 mutation testing and to understand the biological pathways of tumour development. METHODS: Using breast cancer tumour microarrays, immunohistochemical expression of cytokeratin (CK)-5/6, CK-14 and CK-17 was evaluated in breast tumours from BRCA1 families (n = 46), BRCA2 families (n = 40), non-BRCA1/BRCA2 families (n = 358) and familial breast cancer patients with one first-degree relative affected by breast or ovarian cancer (n = 270), as well as from patients with sporadic breast cancer (n = 364). Staining for CK-5/6, CK-14 and CK-17 was compared between these groups and correlated with other clinical and histological factors. RESULTS: CK-5/6, CK-14 and CK-17 were detected mostly among oestrogen receptor (ER)-negative, progesterone receptor (PR)-negative and high-grade tumours. We found the highest percentages of samples positive for these CKs among ER-negative/HER2-negative tumours. In univariate analysis, CK-14 was significantly associated with tumours from BRCA1 (39%; P < 0.0005), BRCA2 (27%; P = 0.011), and non-BRCA1/BRCA2 (21%; P < 0.005) families, as compared with sporadic tumours (10%). However, in multivariate analysis, CKs were not found to be independently associated with BRCA1 or BRCA2 mutation status, and the most effective predictors of BRCA1 mutations were age at onset, HER2 status, and either ER or PR status. CONCLUSION: Although our study confirms that basal CKs can help to identify BRCA1 mutation carriers, this effect was weaker than previously suggested and CKs did not independently predict BRCA1 mutation either from sporadic or familial breast cancer cases. The most effective, independent predictors of BRCA1 mutations were age at onset, HER2 status, and either ER or PR status, as compared with sporadic or non-BRCA1/BRCA2 cancers.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Heinonen, Mira
(author)
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Heikkilä, Päivi
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Kilpivaara, Outi
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Tamminen, Anitta
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Aittomäki, Kristiina
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Blomqvist, CarlUppsala universitet,Enheten för onkologi
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Ristimäki, Ari
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Nevanlinna, Heli
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Uppsala universitetEnheten för onkologi
(creator_code:org_t)
Related titles
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In:Breast cancer research : BCR: Springer Science and Business Media LLC10:1, s. R17-1465-542X
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