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  • Modlin, Irvin M. (author)

Gastroenteropancreatic neuroendocrine tumours

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • 2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-105420
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105420URI
  • https://doi.org/10.1016/S1470-2045(07)70410-2DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116467827URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are fairly rare neoplasms that present many clinical challenges. They secrete peptides and neuroamines that cause distinct clinical syndromes, including carcinoid syndrome. However, many are clinically silent until late presentation with mass effects. Investigation and management should be highly individualised for a patient, taking into consideration the likely natural history of the tumour and general health of the patient. Management strategies include surgery for cure (which is achieved rarely) or for cytoreduction, radiological intervention (by chemoembolisation and radiofrequency ablation), chemotherapy, and somatostatin analogues to control symptoms that result from release of peptides and neuroamines. New biological agents and somatostatin-tagged radionuclides are under investigation. The complexity, heterogeneity, and rarity of GEP NETs have contributed to a paucity of relevant randomised trials and little or no survival increase over the past 30 years. To improve outcome from GEP NETs, a better understanding of their biology is needed, with emphasis on molecular genetics and disease modeling. More-reliable serum markers, better tumour localisation and identification of small lesions, and histological grading systems and classifications with prognostic application are needed. Comparison between treatments is currently very difficult. Progress is unlikely to occur without development of centers of excellence, with dedicated combined clinical teams to coordinate multicentre studies, maintain clinical and tissue databases, and refine molecularly targeted therapeutics.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Öberg, KjellUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)kjellob (author)
  • Chung, Daniel C. (author)
  • Jensen, Robert T. (author)
  • de Herder, Wouter W. (author)
  • Thakker, Rajesh V. (author)
  • Caplin, Martyn (author)
  • Delle Fave, Gianfranco (author)
  • Kaltsas, Greg A. (author)
  • Krenning, Eric P. (author)
  • Moss, Steven F. (author)
  • Nilsson, Ola (author)
  • Rindi, Guido (author)
  • Salazar, Ramon (author)
  • Ruszniewski, Philippe (author)
  • Sundin, Anders,1954-Karolinska Institutet,Uppsala universitet,Enheten för radiologi(Swepub:uu)anderssu (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:The Lancet Oncology9:1, s. 61-721470-20451474-5488

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