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- Kasteng, Frida (författare)
Cost-effectiveness of maintenance rituximab treatment after second line therapy in patients with follicular lymphoma in Sweden
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
- 2009-07-08
- Informa UK Limited,2008
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-105465
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105465URI
- https://doi.org/10.1080/02841860802120028DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10497URI
- https://lup.lub.lu.se/record/1247878URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:117528593URI
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- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- INTRODUCTION: Rituximab has significantly improved the prognosis for patients with both indolent and aggressive non-Hodgkin's lymphoma. An economic evaluation was carried out to assess the cost-effectiveness in Sweden of rituximab as maintenance therapy for patients with follicular lymphoma in remission after second line therapy. MATERIALS AND METHODS: The incremental cost and effectiveness of rituximab maintenance therapy versus observation were evaluated in a health-state transition model. Primary effect measures were quality-adjusted life-years (QALY) and life-years gained (LYG). Model state transitions were calculated based on progression-free and overall survival data from the EORTC20981 trial. The analysis was made from the perspective of the healthcare provider, including direct medical costs presented in euro, 2007 value. Effects and costs were discounted at a 3% annual rate. The stability of the base case results were tested in one-way and probabilistic sensitivity analyses. RESULTS: The evaluation assessed rituximab maintenance therapy to be associated with an incremental cost per QALY gained of euro 12,600 and an incremental cost per LYG of euro 11,200. The average discounted life expectancy for patients on rituximab maintenance was 1.0 year longer than for patients on observation (5.96 vs. 4.94 years). Rituximab maintenance was associated with an additional 0.9 QALY, and total costs per patient were euro 11,500 higher in the treatment arm, compared to observation. DISCUSSION: The results indicate that rituximab maintenance treatment after successful induction therapy for patients with relapsed/refractory follicular lymphoma in Sweden is cost-effective compared to observation.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Erlanson, MartinNorrlands University Hospital, Umeå, Sweden(Swepub:umu)maer0058 (författare)
- Hagberg, HansUppsala universitet,Enheten för onkologi(Swepub:uu)hanshagb (författare)
- Kimby, EvaKarolinska Institutet (författare)
- Relander, ThomasLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-tre (författare)
- Lundkvist, JonasKarolinska Institutet (författare)
- Norrlands University Hospital, Umeå, SwedenEnheten för onkologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Acta Oncologica: Informa UK Limited47:6, s. 1029-360284-186X1651-226X
Internetlänk
- http://dx.doi.org/10.1080/02841860802120028FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105465
- https://doi.org/10.1080/02841860802120028
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-10497
- https://lup.lub.lu.se/record/1247878
- http://kipublications.ki.se/Default.aspx?queryparsed=id:117528593
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- Kasteng, Frida
- Erlanson, Martin
- Hagberg, Hans
- Kimby, Eva
- Relander, Thomas
- Lundkvist, Jonas
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