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A common coding var...
A common coding variant in CASP8 is associated with breast cancer risk
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007-02-11
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Springer Science and Business Media LLC,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-105522
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105522URI
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https://doi.org/10.1038/ng1981DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:12540830URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Dunning, Alison M.
(author)
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Garcia-Closas, Montserrat
(author)
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Balasubramanian, Sabapathy
(author)
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Reed, Malcolm W. R.
(author)
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Pooley, Karen A.
(author)
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Scollen, SerenaKarolinska Institutet
(author)
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Baynes, Caroline
(author)
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Ponder, Bruce A. J.
(author)
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Chanock, Stephen
(author)
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Lissowska, Jolanta
(author)
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Brinton, Louise
(author)
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Peplonska, Beata
(author)
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Southey, Melissa C.
(author)
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Hopper, John L.
(author)
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McCredie, Margaret R. E.
(author)
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Giles, Graham G.
(author)
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Fletcher, Olivia
(author)
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Johnson, Nichola
(author)
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dos Santos Silva, Isabel
(author)
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Gibson, Lorna
(author)
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Bojesen, Stig E.
(author)
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Nordestgaard, Børge G.
(author)
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Axelsson, Christen K.
(author)
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Torres, Diana
(author)
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Hamann, Ute
(author)
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Justenhoven, Christina
(author)
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Brauch, Hiltrud
(author)
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Chang-Claude, Jenny
(author)
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Kropp, Silke
(author)
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Risch, Angela
(author)
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Wang-Gohrke, Shan
(author)
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Schürmann, Peter
(author)
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Bogdanova, Natalia
(author)
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Dörk, Thilo
(author)
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Fagerholm, Rainer
(author)
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Aaltonen, Kirsimari
(author)
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Blomqvist, CarlUppsala universitet,Enheten för onkologi
(author)
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Nevanlinna, Heli
(author)
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Seal, Sheila
(author)
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Renwick, Anthony
(author)
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Stratton, Michael R.
(author)
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Rahman, Nazneen
(author)
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Sangrajrang, Suleeporn
(author)
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Hughes, David
(author)
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Odefrey, Fabrice
(author)
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Brennan, Paul
(author)
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Spurdle, Amanda B.
(author)
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Chenevix-Trench, Georgia
(author)
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Beesley, Jonathan
(author)
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Mannermaa, Arto
(author)
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Hartikainen, Jaana
(author)
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Kataja, Vesa
(author)
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Kosma, Veli-Matti
(author)
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Couch, Fergus J.
(author)
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Olson, Janet E.
(author)
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Goode, Ellen L.
(author)
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Broeks, Annegien
(author)
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Schmidt, Marjanka K.
(author)
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Hogervorst, Frans B. L.
(author)
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Van't Veer, Laura J.
(author)
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Kang, Daehee
(author)
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Yoo, Keun-Young
(author)
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Noh, Dong-Young
(author)
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Ahn, Sei-Hyun
(author)
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Wedrén, Sara
(author)
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Hall, PerKarolinska Institutet
(author)
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Low, Yen-Ling
(author)
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Liu, Jianjun
(author)
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Milne, Roger L
(author)
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Ribas, Gloria
(author)
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Gonzalez-Neira, Anna
(author)
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Benitez, Javier
(author)
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Sigurdson, Alice J.
(author)
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Stredrick, Denise L.
(author)
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Alexander, Bruce H.
(author)
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Struewing, Jeffery P.
(author)
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Pharoah, Paul D. P.
(author)
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Easton, Douglas F.
(author)
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Karolinska InstitutetEnheten för onkologi
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC39:3, s. 352-3581061-40361546-1718
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- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet