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VEGF-B is dispensab...
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
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- Zhang, Fan (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Tang, Zhongshu (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Hou, Xu (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Lennartsson, Johan (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Li, Yang (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Koch, Alexander W. (author)
- Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080, USA
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- Scotney, Pierre (author)
- CSL Limited, Parkville, Victoria 3052, Australia
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- Lee, Chunsik (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Arjunan, Pachiappan (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Dong, Lijin (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Kumar, Anil (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Rissanen, Tuomas T. (author)
- Department of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland
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- Wang, Bin (author)
- Department of Radiology, Medical Imaging Centre of the Affiliated Hospital, Weifang Medical University, Weifang 261042, China
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- Nagai, Nobuo (author)
- Department of Physiology, Kinki University School of Medicine, Osaka 589-8511, Japan
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- Fons, Pierre (author)
- Sanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France
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- Fariss, Robert (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Zhang, Yongqing (author)
- TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
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- Wawrousek, Eric (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Tansey, Ginger (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Raber, James (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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- Fong, Guo-Hua (author)
- Center for Vascular Biology, University of Connecticut, Farmington, CT 06030, USA
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- Ding, Hao (author)
- Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada MB R3E 3P5
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- Greenberg, David A. (author)
- Buck Institute for Age Research, Novato, CA 94945, USA
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- Becker, Kevin G. (author)
- TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
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- Herbert, Jean-Marc (author)
- Sanofi-Aventis Recherche, Cardiovascular-Thrombosis Research Department, 31036 Toulouse Cedex, France
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- Nash, Andrew (author)
- CSL Limited, Parkville, Victoria 3052, Australia
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- Yla-Herttuala, Seppo (author)
- Department of Biotechnology and Molecular Medicine, University of Kuopio, FIN-70211, Kuopio, Finland
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- Cao, Yihai (author)
- Karolinska Institutet
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- Watts, Ryan J. (author)
- Neurodegeneration Labs, Protein Chemistry, Genentech, Inc. San Francisco, CA 94080; dCSL Limited, Parkville, Victoria 3052, Australia
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- Li, Xuri (author)
- National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
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(creator_code:org_t)
- 2009-04-14
- 2009
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:15, s. 6152-6157
- Related links:
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https://www.pnas.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study, using different animal models and multiple types of vascular cells, we revealed that although VEGF-B is dispensable for blood vessel growth, it is critical for their survival. Importantly, the survival effect of VEGF-B is not only on vascular endothelial cells, but also on pericytes, smooth muscle cells, and vascular stem/progenitor cells. In vivo, VEGF-B targeting inhibited both choroidal and retinal neovascularization. Mechanistically, we found that the vascular survival effect of VEGF-B is achieved by regulating the expression of many vascular prosurvival genes via both NP-1 and VEGFR-1. Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases.
Keyword
- Apoptosis
- vascular survival
- ocular neovascularization
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhang, Fan
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Tang, Zhongshu
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Hou, Xu
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Lennartsson, Joh ...
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Li, Yang
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Koch, Alexander ...
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show more...
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Scotney, Pierre
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Lee, Chunsik
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Arjunan, Pachiap ...
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Dong, Lijin
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Kumar, Anil
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Rissanen, Tuomas ...
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Wang, Bin
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Nagai, Nobuo
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Fons, Pierre
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Fariss, Robert
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Zhang, Yongqing
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Wawrousek, Eric
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Tansey, Ginger
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Raber, James
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Fong, Guo-Hua
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Ding, Hao
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Greenberg, David ...
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Becker, Kevin G.
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Herbert, Jean-Ma ...
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Nash, Andrew
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Yla-Herttuala, S ...
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Cao, Yihai
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Watts, Ryan J.
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Li, Xuri
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- Articles in the publication
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Proceedings of t ...
- By the university
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Uppsala University
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Karolinska Institutet