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The unique genomic ...
The unique genomic properties of sex-biased genes: insights from avian microarray data
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- Mank, Judith E. (författare)
- Uppsala universitet,Evolutionsbiologi
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- Hultin-Rosenberg, Lina (författare)
- Uppsala universitet,Evolutionsbiologi
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- Webster, Matthew T. (författare)
- Uppsala universitet,Evolutionsbiologi
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- Ellegren, Hans (författare)
- Uppsala universitet,Evolutionsbiologi
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2008
- 2008
- Engelska.
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 9, s. 148-
- Relaterad länk:
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https://bmcgenomics....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In order to develop a framework for the analysis of sex-biased genes, we present a characterization of microarray data comparing male and female gene expression in 18 day chicken embryos for brain, gonad, and heart tissue. Results: From the 15982 significantly expressed coding regions that have been assigned to either the autosomes or the Z chromosome ( 12979 in brain, 13301 in gonad, and 12372 in heart), roughly 18% were significantly sex- biased in any one tissue, though only 4 gene targets were biased in all tissues. The gonad was the most sex- biased tissue, followed by the brain. Sex- biased autosomal genes tended to be expressed at lower levels and in fewer tissues than unbiased gene targets, and autosomal somatic sex- biased genes had more expression noise than similar unbiased genes. Sex-biased genes linked to the Z- chromosome showed reduced expression in females, but not in males, when compared to unbiased Z- linked genes, and sex- biased Z- linked genes were also expressed in fewer tissues than unbiased Z coding regions. Third position GC content, and codon usage bias showed some sex- biased effects, primarily for autosomal genes expressed in the gonad. Finally, there were several over-represented Gene Ontology terms in the sex- biased gene sets. Conclusion: On the whole, this analysis suggests that sex- biased genes have unique genomic and organismal properties that delineate them from genes that are expressed equally in males and females.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Biology
- Biologi
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