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Evidence for Time-d...
Evidence for Time-dependent Maximum Increase ofFree Radical Damage and Eicosanoid Formation in theBrain as Related to Duration of Cardiac Arrest andCardio-pulmonary Resuscitation
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- Basu, Samar (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Liu, Xiaoli (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Nozari, Ala (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Rubertsson, Sten (författare)
- Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation
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- Miclescu, Adriana (författare)
- Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation
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- Wiklund, Lars (författare)
- Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation
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(creator_code:org_t)
- 2009-07-07
- 2003
- Engelska.
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Ingår i: Free radical research. - : Informa UK Limited. - 1071-5762 .- 1029-2470. ; 37:3, s. 251-256
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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http://uu.diva-porta...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Recovery of neurological function in patients following cardiac arrest and cardiopulmonary resuscitation (CPR) is a complex event. Free radical induced oxidative stress is supposed to be involved in this process. We studied levels of 8-iso-PGF2alpha (indicating oxidative injury) and 15-keto-dihydro-PGF2alpha (indicating inflammatory response) in venous plasma obtained from the jugular bulb in a porcine model of experimental cardiopulmonary resuscitation (CPR) where 2, 5, 8, 10 or 12 min of ventricular fibrillation (VF) was followed by 5 or 8 min of closed-chest CPR. A significant increase of 8-iso-PGF2alpha was observed immediately following restoration of spontaneous circulation in all experiments of various duration of VF and CPR. No such increase was seen in a control group. When compared between the groups there was a duration-dependent maximum increase of 8-iso-PGF2alpha which was greatest in animals subjected to the longest period (VF12 min + CPR8 min) of no or low blood flow. In contrast, the greatest increase of 15-keto-dihydro-PGF2alpha was observed in the 13 min group (VF8 min + CPR5 min). Thus, a time-dependent cerebral oxidative injury occurs in conjunction which cardiac arrest and CPR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Ischemia reperfusion
- Prostaglandins
- Isoprostanes
- Anaesthetics and intensive care
- Anestesiologi och intensivvård
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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