L773:0804 4643
Sökning: L773:0804 4643 > (2005-2009) > Tachykinins in endo...
- Cunningham, Janet L.Uppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi (författare)
Tachykinins in endocrine tumors and the carcinoid syndrome
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
- 2008
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-107837
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107837URI
- https://doi.org/10.1530/EJE-08-0196DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- ObjectiveA new antibody, active against the common tachykinin (TK) C-terminal. was used to study TK expression in patients with endocrine tumors and a possible association between plasma-TK levels and symptoms of diarrhea and flush in patients with metastasizing ileocecal serotonin-producing carcinoid tumors (MSPCs).MethodTK, serotonin and chromogranin A (CgA) immunoreactivity (IR) was studied by immunohistochemistry in tissue samples from 33 midgut carcinoids and 72 other endocrine tumors. Circulating TK (P-TK) and urinary-5 hydroxyindoleacetic acid (U-5HIAA) concentrations were measured in 42 patients with MSPCs before treatment and related to symptoms in patients with the carcinoid syndrome. Circulating CgA concentrations were also measured in 39 out of the 42 patients.ResultsAll MSPCs displayed serotonin and strong TK expression. TK-IR was also seen in all serotonin-producing lung and appendix carcinoids. None of the other tumors examined contained TK-IR cells. Concentrations of P-TK, P-CgA, and U-5HIAA were elevated in patients experiencing daily episodes of either flush or diarrhea, when compared with patients experiencing occasional or none of these symptoms. In a Spearman partial rank test, the correlation of P-TK with daily diarrhea was independent of both U-5HIAA and CgA levels.ConclusionWe found that TK synthesis occurs in serotonin-IR tumors and that P-TK levels are significantly correlated with symptoms of flush and diarrhea in patients with MSPCs. This is. to our knowledge, the first report demonstrating an independent correlation of P-TKs with carcinoid diarrhea, a symptom that is customarily regarded as serotonin mediated. Further investigations may present opportunities for new therapeutic possibilities.
Ämnesord och genrebeteckningar
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Janson, Eva TiensuuUppsala universitet,Onkologisk endokrinologi(Swepub:uu)evatieja (författare)
- Agarwal, SmritiUppsala universitet,Institutionen för medicinska vetenskaper,Onkologisk endokrinologi (författare)
- Grimelius, LarsUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)larsgrim (författare)
- Stridsberg, MatsUppsala universitet,Biokemisk endokrinologi(Swepub:uu)matsstri (författare)
- Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Sammanhörande titlar
- Ingår i:European Journal of Endocrinology159:3, s. 275-2820804-46431479-683X
Internetlänk
Hitta via bibliotek
- European Journal of Endocrinology (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Cunningham, Jane ...
- Janson, Eva Tien ...
- Agarwal, Smriti
- Grimelius, Lars
- Stridsberg, Mats
- Artiklar i publikationen
- European Journal ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
