SwePub
Sök i LIBRIS databas

  Extended search

id:"swepub:oai:DiVA.org:uu-108982"
 

Search: id:"swepub:oai:DiVA.org:uu-108982" > Thyroid-Associated ...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Träisk, Frank (author)

Thyroid-Associated Ophthalmopathy after Treatment for Graves´Hyperthyroidism with Antithyroid Drugs or lodine-131

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • The Endocrine Society,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-108982
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108982URI
  • https://doi.org/10.1210/jc.2009-0747DOI
  • https://lup.lub.lu.se/record/1483918URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119462045URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Context: Previous randomized trials have suggested an association   between radioiodine treatment for Graves' hyperthyroidism and   thyroid-associated ophthalmopathy (TAO).   Objectives: The aim of the study was to compare the occurrence of   worsening or development of TAO in patients who were treated with   radioiodine or antithyroid drugs.   Design: We conducted a randomized trial (TT 96) with a follow-up of 4   yr.   Patients, Setting, and Intervention: Patients with a recent diagnosis   of Graves' hyperthyroidism were randomized to treatment with iodine-131   (163 patients) or 18 months of medical treatment (150 patients). Early   substitution with T-4 was given in both groups.   Main Outcome Measure: Worsening or development of TAO was significantly   more common in the iodine-131 treatment group (63 patients; 38.7%)   compared with the medical treatment group (32 patients; 21.3%) (P <   0.001).   Results: The risk for de novo development of TAO was greater in   patients treated with iodine-131 (53 patients) than with medical   treatment(23patients). However, worsening of TAO in the 41 patients who   had ophthalmopathy already before the start of treatment was not more   common in the radioiodine group (10 patients) than in the medical group   (nine patients). Smoking was shown to influence the risk of worsening   or development of TAO, and smokers treated with radioiodine had the   overall highest risk for TAO. However, in the group of smokers,   worsening or development of TAO was not significantly associated with   the choice of treatment for hyperthyroidism.   Conclusions: Radioiodine treatment is a significant risk factor for   development of TAO in Graves' hyperthyroidism. Smokers run the highest   risk for worsening or development of TAO irrespective of treatment modality.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tallstedt, Leif (author)
  • Abraham-Nordling, MirnaKarolinska Institutet (author)
  • Andersson, Tommy (author)
  • Berg, Gertrud (author)
  • Calissendorff, JanKarolinska Institutet (author)
  • Hallengren, BengtLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-bha (author)
  • Hedner, Pavo (author)
  • Lantz, MikaelLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mla (author)
  • Nyström, Ernst (author)
  • Ponjavic, VesnaLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-vpo (author)
  • Taube, AdamUppsala universitet,Statistiska institutionen(Swepub:uu)adamtaub (author)
  • Törring, OveKarolinska Institutet (author)
  • Wallin, GöranKarolinska Institutet (author)
  • Åsman, PeterLund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups(Swepub:lu)ofta-pas (author)
  • Lundell, GöranKarolinska Institutet (author)
  • Karolinska InstitutetGenomik, diabetes och endokrinologi (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society94:10, s. 3700-37070021-972X1945-7197

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view