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Thyroid-Associated ...
Thyroid-Associated Ophthalmopathy after Treatment for Graves´Hyperthyroidism with Antithyroid Drugs or lodine-131
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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The Endocrine Society,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-108982
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108982URI
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https://doi.org/10.1210/jc.2009-0747DOI
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https://lup.lub.lu.se/record/1483918URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119462045URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Context: Previous randomized trials have suggested an association between radioiodine treatment for Graves' hyperthyroidism and thyroid-associated ophthalmopathy (TAO). Objectives: The aim of the study was to compare the occurrence of worsening or development of TAO in patients who were treated with radioiodine or antithyroid drugs. Design: We conducted a randomized trial (TT 96) with a follow-up of 4 yr. Patients, Setting, and Intervention: Patients with a recent diagnosis of Graves' hyperthyroidism were randomized to treatment with iodine-131 (163 patients) or 18 months of medical treatment (150 patients). Early substitution with T-4 was given in both groups. Main Outcome Measure: Worsening or development of TAO was significantly more common in the iodine-131 treatment group (63 patients; 38.7%) compared with the medical treatment group (32 patients; 21.3%) (P < 0.001). Results: The risk for de novo development of TAO was greater in patients treated with iodine-131 (53 patients) than with medical treatment(23patients). However, worsening of TAO in the 41 patients who had ophthalmopathy already before the start of treatment was not more common in the radioiodine group (10 patients) than in the medical group (nine patients). Smoking was shown to influence the risk of worsening or development of TAO, and smokers treated with radioiodine had the overall highest risk for TAO. However, in the group of smokers, worsening or development of TAO was not significantly associated with the choice of treatment for hyperthyroidism. Conclusions: Radioiodine treatment is a significant risk factor for development of TAO in Graves' hyperthyroidism. Smokers run the highest risk for worsening or development of TAO irrespective of treatment modality.
Subject headings and genre
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Tallstedt, Leif
(author)
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Abraham-Nordling, MirnaKarolinska Institutet
(author)
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Andersson, Tommy
(author)
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Berg, Gertrud
(author)
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Calissendorff, JanKarolinska Institutet
(author)
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Hallengren, BengtLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-bha
(author)
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Hedner, Pavo
(author)
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Lantz, MikaelLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-mla
(author)
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Nyström, Ernst
(author)
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Ponjavic, VesnaLund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)oft-vpo
(author)
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Taube, AdamUppsala universitet,Statistiska institutionen(Swepub:uu)adamtaub
(author)
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Törring, OveKarolinska Institutet
(author)
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Wallin, GöranKarolinska Institutet
(author)
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Åsman, PeterLund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups(Swepub:lu)ofta-pas
(author)
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Lundell, GöranKarolinska Institutet
(author)
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Karolinska InstitutetGenomik, diabetes och endokrinologi
(creator_code:org_t)
Related titles
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In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society94:10, s. 3700-37070021-972X1945-7197
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Träisk, Frank
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Tallstedt, Leif
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Abraham-Nordling ...
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Andersson, Tommy
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Berg, Gertrud
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Calissendorff, J ...
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Hallengren, Beng ...
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Hedner, Pavo
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Lantz, Mikael
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Nyström, Ernst
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Ponjavic, Vesna
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Taube, Adam
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Törring, Ove
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Wallin, Göran
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Åsman, Peter
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Lundell, Göran
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Uppsala University
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