Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: An association study

Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder : An association study

Recent meta-analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs, C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case-control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case-control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta-analyses there is still evidence for association between the MTHFR C677T polymorphism. and schizophrenia. Additional studies are warranted to shed further light on these relationships. (c) 2007 Wiley-Liss, Inc.

Larsson, KristinaUppsala universitet,Institutionen för medicinska vetenskaper (författare)
Vares, Maria (författare)
Hansen, Thomas (författare)
Wang, August G. (författare)
Djurovic, Srdjan (författare)
Rønningen, Kjersti S. (författare)
Andreassen, Ole A. (författare)
Agartz, IngridKarolinska Institutet (författare)
Werge, Thomas (författare)
Terenius, LarsKarolinska Institutet (författare)
Hall, Hakan (författare)
Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Ingår i:American journal of medical genetics. Part B, Neuropsychiatric genetics: Wiley147B:6, s. 976-9821552-4841
Ingår i:American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics: Wiley147B:6, s. 976-9821552-485X

Av författaren/redakt...: Jönsson, Erik G.; Larsson, Kristin ...; Vares, Maria; Hansen, Thomas; Wang, August G.; Djurovic, Srdjan; visa fler...; Rønningen, Kjers ...; Andreassen, Ole ...; Agartz, Ingrid; Werge, Thomas; Terenius, Lars; Hall, Hakan; visa färre...

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