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Network organizatio...
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Hultgård-Ekwall, Anna-Karin H
(författare)
Network organization of interstitial connective tissue cells in the human endolymphatic duct
- Artikel/kapitelEngelska2003
Förlag, utgivningsår, omfång ...
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2016-06-26
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SAGE Publications,2003
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-10926
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10926URI
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https://doi.org/10.1177/002215540305101109DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The human endolymphatic duct (ED) and sac of the inner ear have been suggested to control endolymph volume and pressure. However, the physiological mechanisms for these processes remain obscure. We investigated the organization of the periductal interstitial connective tissue cells and extracellular matrix (ECM) in four freshly fixed human EDs by transmission electron microscopy and by immunohistochemistry. The unique surgical material allowed a greatly improved structural and epitopic preservation of tissue. Periductal connective tissue cells formed frequent intercellular contacts and focally occurring electron-dense contacts to ECM structures, creating a complex tissue network. The connective tissue cells also formed contacts with the basal lamina of the ED epithelium and the bone matrix, connecting the ED with the surrounding bone of the vestibular aqueduct. The interstitial connective tissue cells were non-endothelial and non-smooth muscle fibroblastoid cells. We suggest that the ED tissue network forms a functional mechanical entity that takes part in the control of inner ear fluid pressure and endolymph resorption.
Ämnesord och genrebeteckningar
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Connective Tissue Cells/metabolism/*ultrastructure
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Endolymphatic Duct/metabolism/*ultrastructure
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Epithelium/metabolism/ultrastructure
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Extracellular Matrix/metabolism
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Humans
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Immunohistochemistry
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Microscopy; Electron/methods
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Couloigner, Vincent
(författare)
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Rubin, KristoferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)krisrubi
(författare)
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Rask-Andersen, HelgeUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)helgraan
(författare)
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Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Histochemistry and Cytochemistry: SAGE Publications51:11, s. 1491-5000022-15541551-5044
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