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Reduction of arteri...
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Koppe, Cordelia
(författare)
Reduction of arteriosclerotic nanoplaque formation and size by n-3 fatty acids in patients after valvular defect operation
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-08-13
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S. Karger AG,2009
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-109439
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109439URI
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https://doi.org/10.1159/000229786DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND/METHODS: Coating a silica surface with the isolated lipoprotein receptor heparan sulfate proteoglycan (HS-PG) from arterial endothelium and vascular matrices, we could observe the very earliest stages of arteriosclerotic plaque development by ellipsometric techniques in vitro (patent EP 0 946 876). This so-called nanoplaque formation is represented by the ternary aggregational complex of the HS-PG receptor, lipoprotein particles and calcium ions. The model was validated in several clinical studies on statins in cardiovascular high-risk patients applying their native blood lipoprotein fractions. RESULTS: In 7 patients who had undergone a valvular defect operation, the reduction of arteriosclerotic nanoplaque formation in normal Krebs solution amounted to 6.1 +/- 2.3% (p < 0.0156) and of nanoplaque size to 37.5 +/- 13.2% (p < 0.0312), respectively, after a 3-month therapy with n-3 fatty acids (3 ..3 g daily, Ameu 500 mg). Additionally, the quotient oxLDL/LDL was lowered by 6.8 +/- 2.1% (p < 0.0166), the MDA concentration remained unchanged and the lipoprotein(a) concentration decreased by 15.8 +/- 5.6% (p < 0.0469) in the patients' blood. The concentration of the nanoplaque promoting particles VLDL and total triglycerides was diminished by 34.1 +/- 11.6% (p < 0.0469) and 26.7 +/- 10.8% (p < 0.0156), respectively. Furthermore, the ratio of the strongly atherogenic small dense to the total LDL cholesterol (LDL5+LDL6)/LDLtot decreased by 9.9 +/- 3.0% (p < 0.0174). CONCLUSIONS: A combinatorial regression analysis revealed a basis for a mechanistic explanation of nanoplaque reduction under n-3 fatty acid treatment. This effect was possibly due to the beneficial changes in lipid concentrations and an attenuation of the risk factors oxLDL/LDL and (LDL5+LDL6)/LDLtot.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rodríguez, Miguel
(författare)
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Winkler, Karl
(författare)
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Pietzsch, Jens
(författare)
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Neumann, Konrad
(författare)
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Hiemann, Nicola E
(författare)
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Hetzer, Roland
(författare)
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Malmsten, MartinUppsala universitet,Institutionen för farmaci(Swepub:uu)mamal991
(författare)
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Siegel, GünterUppsala universitet,Institutionen för farmaci(Swepub:uu)gunsi640
(författare)
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Uppsala universitetInstitutionen för farmaci
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Forschende Komplementärmedizin: S. Karger AG16:4, s. 237-2451424-73641424-7372
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Ingår i:Complementary Medicine Research: S. Karger AG16:4, s. 237-2452504-20922504-2106
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