Assessment of lipids in skeletal muscle by LCModel and AMARES

PURPOSE: To process single voxel spectra of the human skeletal muscle by using an advanced method for accurate, robust, and efficient spectral fitting (AMARES) and by linear combination of model spectra (LCModel). To determine absolute concentrations of extra- (EMCL) and intramyocellular lipids (IMCL). MATERIALS AND METHODS: Single-voxel proton magnetic resonance spectroscopy (PRESS) was used to obtain the spectra of the calf muscles. Unsuppressed water line was used as a concentration reference. A new prior knowledge for AMARES was proposed to estimate the concentrations of EMCL and IMCL. The prior knowledge was derived from the spectrum of vegetable oil. The results were compared with the values estimated by LCModel. Absolute concentrations of total lipid content in millimoles per kilogram wet weight were used for the comparisons. RESULTS: Absolute concentrations of total lipid content in skeletal muscle were estimated by AMARES and LCModel. Very good correlation of the total fat (EMCL + IMCL) and IMCL concentrations was achieved between both data processing approaches. CONCLUSION: Assessment the absolute concentrations of muscular lipids by AMARES and LCModel can be performed with comparable accuracy.

Johansson, LarsUppsala universitet,Enheten för radiologi(Swepub:uu)larsjoha (författare)
Ortiz-Nieto, FranciscoUppsala universitet,Enheten för radiologi(Swepub:uu)fraor613 (författare)
Ahlström, HåkanUppsala universitet,Enheten för radiologi(Swepub:uu)hakanahl (författare)
Uppsala universitetEnheten för radiologi (creator_code:org_t)

Ingår i:Journal of Magnetic Resonance Imaging: Wiley30:5, s. 1124-11291053-18071522-2586

Av författaren/redakt...: Weis, Jan; Johansson, Lars; Ortiz-Nieto, Fra ...; Ahlström, Håkan

Om ämnet

LANTBRUKSVETENSKAPER: LANTBRUKSVETENSK ...; och Veterinärmedicin; och Klinisk vetenska ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.